REMISSION AND RELAPSE IN SUBJECTS WITH PANIC DISORDER AND PANIC WITH AGORAPHOBIA - A PROSPECTIVE SHORT-INTERVAL NATURALISTIC FOLLOW-UP
REMISSION AND RELAPSE IN SUBJECTS WITH PANIC DISORDER AND PANIC WITH AGORAPHOBIA - A PROSPECTIVE SHORT-INTERVAL NATURALISTIC FOLLOW-UP
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DOI：
10.1097/00005053-199405000-00007
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发表时间：
1994-05-01
影响因子：
1.9
通讯作者：
LAVORI, PW
中科院分区：
文献类型：
--
作者：
KELLER, MB;YONKERS, KA;LAVORI, PW
本文报道了参加哈佛/布朗焦虑研究项目的309例单纯性惊恐障碍和惊恐伴广场恐怖症患者的病程，该项目是一项对DSM-III-R定义的焦虑障碍患者的前瞻性纵向研究。1年时，单纯性恐慌症完全缓解的概率为0.39，伴有广场恐惧症的恐慌症完全缓解的概率为0.17。当缓解标准不那么严格时，这些综合征的缓解时间仍存在类似差异。然而，即使缓解需要较少的改善，也会有很大比例的受试者处于发作状态，对于那些缓解的受试者，复发发生得很快，表明疾病的慢性和复发性病程。这是第一个纵向的，前瞻性的，自然主义的研究，对一个大队列的焦虑症患者进行定期的，结构化的，短间隔的随访。我们的研究结果是一致的，惊恐障碍有一个慢性病程，缓解后复发率高，当广场恐怖症是症状的一部分时，发作时间更长。
This article reports on the course of uncomplicated panic disorder and panic with agoraphobia on 309 patients participating in the Harvard/Brown Anxiety Research Project, a prospective longitudinal study of patients with DSM-III-R-defined anxiety disorders. At 1 year, there was a .39 probability of full remission for uncomplicated panic disorder and a .17 probability of full remission for panic disorder with agoraphobia. Similar differences in time to remission for these syndromes were still found when criteria for remission were made less stringent. However, even requiring less improvement for remission left a large percentage of subjects in an episode, and for those that remitted, relapse occurred quickly, indicating a chronic and recurrent course of illness. This is the first longitudinal, prospective, naturalistic study on a large cohort of subjects with anxiety disorders to have regular, structured, short-interval follow-up. Our results are consistent with the view that panic disorder has a chronic course with high rates of relapse after remission and longer episodes when agoraphobia is a part of the constellation of symptoms.