Epidemiologic considerations to assess altered DNA methylation from environmental exposures in cancer
Epidemiologic considerations to assess altered DNA methylation from environmental exposures in cancer
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DOI：
10.1111/j.1749-6632.2003.tb05973.x
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发表时间：
2003-01-01
期刊：
影响因子：
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通讯作者：
Hayes, RB
中科院分区：
文献类型：
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作者：
Moore, LE;Huang, WY;Hayes, RB
人群中的流行病学研究已经确定了广泛的癌症风险因素。基因破坏剂一直是癌症流行病学的主要焦点;然而，所有外源性物质都不直接与DNA相互作用。一些外源性因子诱导表观遗传变化。鉴于此，测量表观基因组变化的标记物也必须纳入分子流行病学研究。我们回顾了目前的理解外源性药物的影响，包括：微量营养素，化疗药物，金属，和其他人，对DNA甲基化。描述了两类基因：（1）可以改变对异常DNA甲基化的易感性的基因和（2）当通过DNA甲基化沉默时增加癌症易感性的基因。将DNA甲基化状态的标记物结合到环境暴露对疾病影响的病因学研究中的方法（例如，癌症）进行了讨论。
Epidemiologic studies in human populations have identified a broad spectrum of risk factors for cancer. Gene-damaging agents have been a primary focus of cancer epidemiology; however, all xenobiotics do not interact with DNA directly. Some exogenous agents induce epigenetic changes. In view of this, markers that measure changes to the epigenome must also be incorporated into molecular epidemiologic studies. We review the current understanding of the impact of exogenous agents including: micronutrients, chemotherapeutic agents, metals, and others, on DNA methylation. Two categories of genes are described: (1) genes that can alter susceptibility to aberrant DNA methylation and (2) genes that increase susceptibility to cancer when they are silenced through DNA methylation. Methods for incorporating markers of DNA methylation status into etiologic investigations of the impact of environmental exposures on disease (e.g., cancer) are discussed.