TREATMENT OF STAGE-I AND STAGE-II ORAL TONGUE CANCER
TREATMENT OF STAGE-I AND STAGE-II ORAL TONGUE CANCER
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DOI：
10.1002/hed.2880150407
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发表时间：
1993-07-01
影响因子：
2.9
通讯作者：
WOLF, PF
中科院分区：
文献类型：
--
作者：
LYDIATT, DD;ROBBINS, KT;WOLF, PF
我们回顾了 156 名先前未经治疗的 T1 和 T2 期口腔舌鳞状细胞癌患者，以确定淋巴结转移的发生率，以及选择性颈清扫术是否影响局部/区域控制或生存。患者被分为两个非随机组：第 1 组，仅口内舌切除术（102 名患者）；第 1 组，仅口腔内舌切除术（102 名患者）；第 2 组，口内舌切除术加颈清扫术（54 名患者）。分析显示肿瘤位置、组织学分化、边缘状态或临床外观没有显着差异；然而，神经周围侵犯对生存和局部/区域控制产生显着不利影响。在第 1 组患者中，16.5% 随后出现颈部转移，第 2 组中 20.4% 的患者出现隐匿性淋巴结病。随后出现淋巴结的第 1 组患者的生存率和局部/区域控制率分别为 33% 和 50%。第 2 组隐匿性转移患者的生存率和局部/区域控制率分别为 55% 和 91%。我们认为选择性颈清扫术适用于早期口腔舌癌。
We reviewed 156 previously untreated patients with squamous cell carcinoma of the oral tongue staged T1 and T2 to determine the incidence of nodal metastasis, and if elective neck dissection affected local/regional control or survival. Patients were divided into two nonrandomized groups: group 1, intraoral glossectomy only (102 patients); and group 2, intraoral glossectomy plus neck dissection (54 patients). Analysis revealed no significant differences for tumor location, histologic differentiation, status of margins, or clinical appearance; however, perineural invasion significantly adversely affected survival and local/regional control. In group 1 patients, 16.5% subsequently developed cervical metastasis, and 20.4% of patients in group 2 had occult nodal disease. The survival and local/regional control for group 1 patients subsequently developing nodes was 33% and 50%, respectively. The survival and local/regional control for group 2 patients with occult metastasis was 55% and 91%, respectively. We believe elective neck dissection is indicated for early staged oral tongue cancer.