COMPLETE CODING SEQUENCE OF RAT TYROSINE-HYDROXYLASE MESSENGER-RNA
COMPLETE CODING SEQUENCE OF RAT TYROSINE-HYDROXYLASE MESSENGER-RNA
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DOI：
10.1073/pnas.82.2.617
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发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
MALLET, J
中科院分区：
文献类型：
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作者：
GRIMA, B;LAMOUROUX, A;MALLET, J
通过使用先前表征的克隆pTH-1，从大鼠PC 12文库中鉴定出对酪氨酸羟化酶[酪氨酸3-单加氧酶，L-酪氨酸，四氢蝶啶：氧氧化还原酶（3-羟基化），EC 1.14.16.2]特异的几个克隆。其中最完整的是pTH-51，长1758个碱基对，覆盖了mRNA的大部分长度，包括整个编码区和3“非翻译区。该多肽的估计分子量为55，903，并讨论了它的一些特征。
Several clones specific for tyrosine hydroxylase [tyrosine 3-monooxygenase, L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] were identified from a rat PC12 library by using the previously characterized clone pTH-1. The most complete of these, pTH-51, is 1758 base pairs long and covers most of the length of the mRNA, including the entire coding and 3'' untranslated region. The polypeptide has an estimated MW of 55,903 and some of its characteristic features are discussed.