Changing international trends in mortality rates for liver, biliary and pancreatic tumours
Changing international trends in mortality rates for liver, biliary and pancreatic tumours
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DOI：
10.1016/s0168-8278(02)00297-0
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发表时间：
2002-12-01
影响因子：
25.7
通讯作者：
Thomas, HC
中科院分区：
文献类型：
--
作者：
Khan, SA;Taylor-Robinson, SD;Thomas, HC
背景/目的：肝细胞癌的年龄标准化死亡率在一些国家正在上升。然而，在英格兰和威尔士，我们以前报道过肝内胆管癌的死亡率增加。胆管癌在大多数其他工业化国家的趋势是未知的。为了进一步研究肝胆和胰腺肿瘤的趋势，我们分析了来自美国、日本、澳大利亚和欧洲的死亡率数据。方法：从世界卫生组织死亡率数据库中获得1979年至1998年男性和女性肝脏肿瘤、胆囊和肝外胆管树肿瘤和胰腺肿瘤的标准化死亡率。结果：我们证实了先前报道的肝细胞癌增加，但也发现其他国家也有增加，特别是澳大利亚（男性3年平均从1.20上升到2.27）。在所有研究的国家中，男性肝内胆管细胞癌的死亡率都有所增加，其中澳大利亚（从0.10增加到0.70）以及英格兰和威尔士（从0.20增加到0.83）的增幅最大。结论：我们提出了一个迄今为止未报告的四大洲肝内胆管细胞癌年龄标准化死亡率的上升。原因尚不清楚。不能完全排除诊断技术的改进和死亡证明分类错误对观察到的趋势的影响。未来的研究应包括流行病学研究，以检查可能的病例聚集性并调查潜在的病原学和宿主因素。(C)2002年欧洲肝脏研究协会。由Elsevier Science B. V.出版，版权所有。
Background/Aims: The age-standardized mortality rate for hepatocellular carcinoma is increasing in several countries. However, in England and Wales we previously reported an increase in mortality rates from intrahepatic cholangiocarcinoma. Trends in cholangiocarcinoma in most other industrialized countries are unknown. To further study trends in hepatobiliary and pancreatic tumours, we analysed mortality data from the United States, Japan, Australia and Europe.Methods: Age-standardized mortality rates for men and women for subcategories of liver tumours, tumours of the gall bladder and extrahepatic biliary tree and pancreas from 1979 to 1998 were obtained from the World Health Organization mortality database.Results: We confirmed previously reported increases in hepatocellular carcinoma, but also found increases in other countries, particularly Australia (3-year average rise from 1.20 to 2.27, men). Mortality for intrahepatic cholangiocarcinoma increased in men in all countries studied, with the largest increases in Australia (from 0.10 to 0.70) and England and Wales (from 0.20 to 0.83).Conclusions: We present a hitherto unreported rise in age-standardized mortality rates from intrahepatic cholangiocarcinoma across four continents. The cause remains uncertain. An impact on the observed trends of improved diagnostic techniques and death certificate misclassification cannot be completely ruled out. Future research should include epidemiological studies to examine possible case-clustering and investigation of potential aetiological and host factors. (C) 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.