Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment
Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment
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DOI：
10.1002/syn.21622
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发表时间：
2013-03-01
期刊：
影响因子：
2.3
通讯作者：
Nyengaard, Jens R.
中科院分区：
文献类型：
--
作者：
Chen, Fenghua;Wegener, Gregers;Nyengaard, Jens R.
抑郁症及其治疗与许多神经可塑性事件有关，如大脑离散区域的神经发生和突触重塑。这些事件与能源供应变化之间的联系尚未得到调查。在这里，我们研究了线粒体可塑性的变化及其与海马神经可塑性形态学改变的相关性，两者都与抑郁表型相关，并且在抗抑郁药丙咪嗪治疗后。采用基于设计的体视学方法，对具有抑郁行为遗传易感性的SpragueDawley （SD）和Flinders （Flinders-sensitive line， FSL）大鼠及其对照Flinders-resistant line （FRL）大鼠海马CA1区线粒体的数量和体积进行了研究。结果显示，与FRL组相比，未经治疗的FSL生理盐水组CA1线粒体数量明显减少。然而，FSL生理盐水组的线粒体平均体积明显大于FRL生理盐水组。治疗后，与FSL生理盐水组相比，FSL丙咪嗪组线粒体数量显著增加。丙咪嗪对SD大鼠线粒体数量无显著影响。我们的研究结果表明，抑郁症可能与海马线粒体可塑性损伤有关，抗抑郁药物治疗可能抵消结构损伤。此外，线粒体形态和数量的变化是神经可塑性的一致特征。突触,2013年。(C) 2012 Wiley期刊公司
Depressive disorders and the treatment thereof have been associated with a number of neuroplastic events, such as neurogenesis and synaptic remodeling in discrete areas of the brain. The associations of these events in changes regarding the energy supply have not been investigated. Here, we investigated the changes in mitochondrial plasticity and its correlation to morphological alterations of neuroplasticity in the hippocampus, both associated with a depressive phenotype, and after treatment, with antidepressant imipramine. Design-based stereological methods were used to estimate the number and volume of mitochondria in CA1 of the hippocampus in two different strains of rats, the SpragueDawley (SD) and Flinders rats, which display a genetic susceptibility to depressive behavior, the Flinders-sensitive line (FSL) and their corresponding controls, the Flinders-resistant line (FRL). Results showed a significantly reduced number of mitochondria in CA1, which was significantly smaller in the untreated FSL saline group compared to the FRL group. However, the mean volume of mitochondria was significantly larger in the FSL saline group compared to the FRL saline group. Following treatment, the FSL imipramine group showed a significant increase in the number of mitochondria compared to the FSL saline group. Treatment with imipramine in the SD rats did not induce significant differences in the number of mitochondria. Our results indicate that depression may be related to impairments of mitochondrial plasticity in the hippocampus and antidepressant treatment may counteract with the structural impairments. Moreover, the changes in mitochondrial morphology and number are a consistent feature of neuroplasticity. Synapse, 2013. (C) 2012 Wiley Periodicals, Inc.