Can We Measure Corneal Biomechanical Changes After Collagen Cross-Linking in Eyes With Keratoconus? A Pilot Study
Can We Measure Corneal Biomechanical Changes After Collagen Cross-Linking in Eyes With Keratoconus? A Pilot Study
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DOI：
10.1097/ico.0b013e318190734d
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发表时间：
2009-06-01
期刊：
影响因子：
2.8
通讯作者：
Zadok, David
中科院分区：
文献类型：
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作者：
Goldich, Yakov;Barkana, Yaniv;Zadok, David
目的：目的：评价人角膜在用UV-A-核黄素角膜胶原交联（CXL）治疗圆锥角膜后生物力学特性的变化。设计：单中心、前瞻性、介入性研究。方法：年龄26.5 ± 5.7（平均SD）岁的进行性圆锥角膜患者的10只眼睛接受UV-A-核黄素CXL治疗，并使用眼反应分析仪（ORA）进行评估。测量角膜滞后（CH）、角膜阻力因子（CRF）、Goldmann相关眼压（IOPg）和角膜代偿眼压（IOPcc）。还通过Goldmann压平眼压计（GAT-IOP）测量眼内压。在术前、治疗后第1周、第1、3和6个月对患者进行ORA评估。结果：交联治疗后CH和CRF均一过性升高，但差异无统计学意义（P > 0.3）。术后1周和1个月时IOPcc和IOPg显著升高，但术后1周和1个月时差异无统计学意义（P> 0.04）。结论：圆锥角膜CXL术后1周、1个月、3个月GAT-IOP明显升高（P < 0.01）。在我们的研究中，CXL治疗后IOPcc、IOPg和GAT-IOP值短暂升高。目前尚不清楚这是否反映了角膜变化或眼内压真实升高引起的测量伪影。
Purpose: To assess changes in biomechanical properties of human cornea after treatment of keratoconus with UV-A-riboflavin corneal collagen cross-linking (CXL).Design: Single-center, prospective, interventional studyMethods: Ten eyes of 10 patients aged 26.5 +/- 5.7 (mean SD) years with progressive keratoconus were treated with UV-A-riboflavin CXL and assessed with the Ocular Response Analyzer (ORA) that measured corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal compensated intraocular pressure (IOPcc). Intraocular pressure was also measured by Goldmann applanation tonometry (GAT-IOP). Patients were assessed with ORA preoperatively, at week 1, months 1, 3, and 6 after treatment. Postoperative measurements at each visit were compared with preoperative values.Results: CH and CRF were transiently elevated after cross-linking treatment, with the difference not statistically significant (P > 0.3). IOPcc and IOPg were statistically significantly higher at 1 week and I month but not subsequently (P < 0.04). GAT-IOP was statistically significantly higher at I week and at I and 3 months (P < 0.01).Conclusions: There were no significant differences in corneal biomechanical properties, as measured with the ORA parameters CH and CRF, after CXL in keratoconus. IOPcc, IOPg, and GAT-IOP values were transiently elevated after CXL treatment in our study. Whether this reflects a measurement artifact resulting from corneal changes or true elevation of intraocular pressure is unclear.