DERMAL ABSORPTION POTENTIAL OF INDUSTRIAL-CHEMICALS - CRITERIA FOR SKIN NOTATION
DERMAL ABSORPTION POTENTIAL OF INDUSTRIAL-CHEMICALS - CRITERIA FOR SKIN NOTATION
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DOI：
10.1002/ajim.4700170507
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发表时间：
1990-01-01
影响因子：
3.5
通讯作者：
DROZ, PO
中科院分区：
文献类型：
--
作者：
FISEROVABERGEROVA, V;PIERCE, JT;DROZ, PO
建议根据 132 种化学品的物理性质预测的皮肤渗透率（通量）作为工业化学品皮肤吸收潜力的指标。该预测是针对有机非电解质而设计的。建议使用两个参考值作为皮肤标记的标准： 1) 皮肤吸收潜力，与将非挥发性化学物质的剂量或挥发性化学物质的生物水平提高 30%（高于 TLV-TWA 吸入暴露期间观察到的水平 30%）的皮肤吸收有关，在解释生物监测获得的数据时，应考虑属于此类别的化学物质的皮肤吸收； 2) 潜在的皮肤毒性，与仅吸入 TLV-TWA 期间观察到的水平相比，其生物水平增加了三倍，与皮肤吸收有关。属于此类别的化学品应带有皮肤符号。对于 TLV 以防止刺激和不适为基础的化学品，毒性标准可能无效。
A dermal penetration rate (flux), predicted from physical properties of 132 chemicals, is suggested as an index of the dermal absorption potential of industrial chemicals. The prediction is designed for organic nonelectrolytes. Two reference values are recommended as criteria for skin notation: 1) dermal absorption potential, which relates to dermal absorption raising the dose of nonvolatile chemicals or biological levels of volatile chemicals 30% above those observed during inhalation exposure of TLV-TWA only-dermal absorption of chemicals belonging to this category should be considered when data obtained by biological monitoring are interpreted; and 2) dermal toxicity potential, which relates to dermal absorption that triples biological levels as compared with levels observed during inhalation exposure to TLV-TWA only. Chemicals belonging in this catergory should carry a skin notation. The toxicity criteria may not be valid for chemicals whose TLVs are based on preventing irritation and discomfort.