Etiology of acute childhood encephalitis at The Hospital for Sick Children, Toronto, 1994-1995
Etiology of acute childhood encephalitis at The Hospital for Sick Children, Toronto, 1994-1995
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DOI：
10.1086/516301
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发表时间：
1998-02-01
影响因子：
11.8
通讯作者：
MacGregor, D
中科院分区：
文献类型：
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作者：
Kolski, H;Ford-Jones, EL;MacGregor, D
145例因脑炎样疾病住院的患者中，50例住院时间大于或等于72小时的患者接受了标准化微生物检查，20例(40%)确诊或可能为病原体，包括肺炎支原体(9例)。肺炎和肠道病毒(2例)，单纯疱疹病毒(4例)，EB病毒(1例)，人类疱疹病毒6型(HHV-6)(1例)，HHV-6和A型流感病毒(1例)，A型流感病毒(1例)，鲍瓦桑病毒(1例)，13例(26%)，包括9例肺炎支原体。临床表现包括发热(80%)、癫痫(78%)、局灶性神经学改变(78%)和意识减退(47%)，入院时与入院后相比，其发生率分别为：细胞增多症，59%比63%；脑电异常，87%比96%；神经影像异常，分别为37%和69%。出院时体检正常32%(16例)，死亡2%(1例)，运动障碍26%(13例)；全球神经缺陷，16%(严重，6例；轻度，2例)；精神状态改变，14%(7例)；视力缺陷，8%(4例)；听力障碍，2%(1例)。
Of 145 patients admitted to our hospital because of encephalitis-like illness, 50 patients hospitalized for greater than or equal to 72 hours underwent standardized microbiological investigations, A confirmed or probable etiologic agent was identified in 20 cases ( 40%), including Mycoplasma pneumoniae (9 cases), ill. pneumoniae and enterovirus (2), herpes simplex virus (4), Epstein-Barr virus (1), human herpesvirus 6 (HHV-6) (1), HHV-6 and influenza virus type A (1), influenza virus type A(1), and Powassan virus (1), In 13 cases (26%), a possible pathogen was identified, including M. pneumoniae in nine cases. Presenting features included fever (80% of patients), seizures (78%), focal neurological findings (78%), and decreased consciousness (47%), The frequency of findings at the time of admission vs, later in hospitalization was as follows: pleocytosis, 59% vs, 63%; electroencephalogram abnormalities, 87% vs. 96%; and neuroimaging abnormalities, 37% vs. 69%, respectively, The outcomes at the time of discharge were as follows: normal results of physical examination, 32% (16) of the patients; death, 2% (1); motor difficulties, 26% (13); global neurological deficits, 16% (severe, 6; mild, 2); mental status changes, 14% (7); visual defects, 8% (4); and hearing impairment, 2% (1).