Genome-wide redistribution of BRD4 binding sites in transformation resistant cells.
Genome-wide redistribution of BRD4 binding sites in transformation resistant cells.
复制标题
转化抗性细胞中 BRD4 结合位点的全基因组重新分布。
DOI：
10.1016/j.gdata.2014.11.005
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Fernandez,Patricia
中科院分区：
文献类型：
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作者：
Si,Han;Scaffidi,Paola;Merchant,Anand;Cam,Maggie;Stahlberg,Eric;Misteli,Tom;Fernandez,Patricia
Hutchinson–Gilford progeria syndrome (HGPS) patients do not develop cancer despite a significant accumulation of DNA damage in their cells. We have recently reported that HGPS cells are refractory to experimental oncogenic transformation and we identified the bromodomain-containing 4 protein (BRD4) as a mediator of the transformation resistance. ChIP-sequencing experiments revealed distinct genome-wide binding patterns for BRD4 in HGPS cells when compared to control wild type cells. Here we provide a detailed description of the ChIP-seq dataset (NCBI GEO accession number GSE61325), the specific and common BRD4 binding sites between HGPS and control cells, and the data analysis procedure associated with the publication by Fernandez et al., 2014 in Cell Reports 9, 248-260 [1].
