Clinical and genetic correlates of serum aldosterone in the community: The Framingham Heart Study
Clinical and genetic correlates of serum aldosterone in the community: The Framingham Heart Study
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DOI：
10.1016/j.amjhyper.2004.12.005
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发表时间：
2005-05-01
影响因子：
3.2
通讯作者：
Vasan, RS
中科院分区：
文献类型：
--
作者：
Kathiresan, S;Larson, MG;Vasan, RS
背景：我们在基于社区的大型样本中调查了血清醛固酮水平个体间变异的环境和遗传来源。方法：我们使用多元线性回归检查了 2891 名 Framingham 后代研究参与者（53.2% 女性，平均年龄 59 岁）的血清醛固酮与血管危险因素、尿钠和候选单核苷酸多态性的关系。使用多变量逻辑回归来确定高（最高四分位数）和低（最低四分位数）血清醛固酮值的预测因子。我们通过方差分量法估计了血清醛固酮的遗传力，并通过 10 cM 密度基因组扫描评估了关联性。 结果：与较高血清醛固酮水平相关的临床变量包括女性、利尿治疗和较高的总/高密度脂蛋白胆固醇比率。高尿钠排泄、绝经后状态（未经激素替代治疗）、脉压增加和普遍的心血管疾病与血清醛固酮值较低有关。尿钠与血清醛固酮的相关性最强（R-2 = 10%）。醛固酮合酶 (CYP11B2c.1-344C > T) 和盐皮质激素受体 (NR3C2c.754A > G) 基因的基因型不同，血清醛固酮水平没有差异。血清醛固酮的估计遗传力为0.10。在多点连锁分析中，没有染色体区域的对数得分> 1。结论：我们观察到血清醛固酮与血管危险因素之间存在复杂的关系。遗传因素对血清醛固酮水平的影响不大。 (c) 2005 年美国高血压杂志有限公司。
Background: We investigated the environmental and genetic sources of interindividual variability in serum aldosterone level in a large, community-based sample.Methods: We examined the relation of serum aldosterone to vascular risk factors, urine sodium, and candidate single nucleotide polymorphisms in 2891 Framingham Offspring Study participants (53.2% women, mean age 59 years) using multivariable linear regression. Multivariable logistic regression was used to identify predictors of high (top quartile) and low (lowest quartile) serum aldosterone values. We estimated heritability of serum aldosterone via variance-component methods and evaluated linkage via a 10-cM-density genome scan.Results: Clinical variables related to higher serum aldosterone level included female sex, diuretic treatment, and a higher total/high density lipoprotein cholesterol ratio. A high urinary sodium excretion, postmenopausal status (without hormone replacement therapy), increased pulse pressure, and prevalent cardiovascular disease were related to lower serum aldosterone values. Urinary sodium was the strongest correlate of serum aldosterone (R-2 = 10%). Serum aldosterone levels did not differ by genotype in the aldosterone synthase (CYP11B2c. 1-344C > T) and the mineralocorticoid receptor (NR3C2c.754A > G) genes. The estimated heritability of serum aldosterone was 0.10. No chromosomal region attained a log-of-the-odds score > 1 in multipoint linkage analysis.Conclusions: We observed a complex relation between serum aldosterone and vascular risk factors. The genetic contribution to serum aldosterone level was modest. (c) 2005 American Journal of Hypertension, Ltd.