Evolutionary changes of metabolic networks and their biosynthetic capacities
Evolutionary changes of metabolic networks and their biosynthetic capacities
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DOI：
10.1049/ip-syb:20060014
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发表时间：
2006-09-01
期刊：
影响因子：
--
通讯作者：
Kahn, D.
中科院分区：
文献类型：
--
作者：
Ebenhoeh, O.;Handorf, T.;Kahn, D.
不同物种的代谢网络在结构设计上表现出很大的差异。在这项工作中，研究了与代谢网络结构相关的代谢功能特性的演变。使用代谢进化的贝叶斯网络模型从当代物种的新陈代谢推断出祖先物种的新陈代谢。随后，使用最近开发的网络扩展方法对这些网络进行分析。该方法允许对代谢网络进行结构分析，并在提供某些外部资源时根据其合成能力对网络功能进行量化。研究了一种特定网络功能的进化动力学：葡萄糖的代谢扩张。
The metabolic networks of different species show a large variety in their structural design. In this work, the evolution of functional properties of metabolism in relation with metabolic network structure is investigated. The metabolism of ancestral species is inferred from the metabolism of contemporary species using a Bayesian network model for metabolism evolution. Subsequently, these networks are analysed with the recently developed method of network expansion. This method allows for a structural analysis of metabolic networks as well as a quantification of network functions in terms of their synthesising capacities when they are provided with certain external resources. The evolutionary dynamics of one particular network function: the metabolic expansion of glucose is investigated.