Human neural stem cells and astrocytes, but not neurons, suppress an allogeneic lymphocyte response
Human neural stem cells and astrocytes, but not neurons, suppress an allogeneic lymphocyte response
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DOI：
10.1016/j.scr.2008.06.002
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发表时间：
2009-01-01
影响因子：
1.2
通讯作者：
Odeberg, Jenny
中科院分区：
文献类型：
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作者：
Akesson, Elisabet;Wolmer-Solberg, Nina;Odeberg, Jenny
人神经干细胞及其衍生物的移植是治疗神经退行性疾病和创伤性神经系统病变的一种有前途的方法。一个重要的问题是细胞移植和宿主相互作用导致什么样的免疫反应。以前，我们报道，人类神经干细胞，尽管表达MHC I类和II类分子，不触发同种异体T细胞反应。在此，进一步研究了人NSC以及分化的神经细胞的免疫活性。星形胶质细胞表达MHC I类和II类分子的程度相当于神经干细胞，而神经元只表达MHC I类分子。无论是神经干细胞还是分化的细胞都没有引发同种异体淋巴细胞反应。相反，这些潜在的供体NSC和星形胶质细胞，而不是神经元，表现出对同种异体免疫应答的抑制作用。由NSC介导的抑制作用最可能涉及细胞-细胞相互作用。当在啮齿动物的急性脊髓损伤模型中测试人NSC的免疫原性时，触发了异种排斥反应。因此，人NSC和它们衍生的星形胶质细胞不启动，而是抑制同种异体反应，白色它们不能阻断异种环境中的移植排斥。(C)2008 Elsevier B. V.保留所有权利。
Transplantation of human neural stem cells (NSCs) and their derivatives is a promising future treatment for neurodegenerative disease and traumatic nervous system lesions. An important issue is what kind of immunological reaction the cellular transplant and host interaction with result in. Previously, we reported that human NSCs, despite expressing MHC class I and class II molecules, do not trigger an allogeneic T cell response. Here, the immunocompetence of human NSCs, as well as differentiated neural cells, was further studied. Astrocytes expressed both MHC class I and class II molecules to a degree equivalent to that of the NSCs, whereas neurons expressed only MHC class I molecules. Neither the NSCs nor the differentiated cells triggered an allogeneic lymphocyte response. Instead, these potential donor NSCs and astrocytes, but not the neurons, exhibited a suppressive effect on an allogeneic immune response. The suppressive effect mediated by NSCs most likely involves cell-cell interaction. When the immunogenicity of human NSCs was tested in an acute spinal cord injury model in rodent, a xenogeneic rejection response was triggered. Thus, human NSCs and their derived astrocytes do not initiate, but instead suppress, an allogeneic response, white they cannot block a graft rejection in a xenogeneic setting. (C) 2008 Elsevier B.V. All rights reserved.