Pharmacokinetics and tissue distribution of anidulafungin in rats
Pharmacokinetics and tissue distribution of anidulafungin in rats
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DOI：
10.1128/aac.01596-07
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发表时间：
2008-07-01
影响因子：
4.9
通讯作者：
Dowei, James
中科院分区：
文献类型：
--
作者：
Damle, Bharat;Stogniew, Martin;Dowei, James
本研究评估了阿尼芬净在大鼠中的组织分布。阿尼芬净迅速分布到组织中，在30分钟内达到峰值浓度，并在72小时内保持高于常见病原体MIC的水平。在易受真菌感染的组织（肝、肺、脾、肾）中，暴露量是血浆中的9- 12倍。
This study assessed the tissue distribution of anidulafungin in rats. Anidulafungin rapidly distributed into tissues, achieving peak concentrations within 30 min, and maintained levels above MICs for common pathogens over 72 h. In tissues susceptible to fungal infection (liver, lung, spleen, kidney), exposure was 9- to 12-fold higher than in plasma.