Intracardiac, intravascular, two-dimensional, high-frequency ultrasound imaging of pulmonary artery and its branches in humans and animals.
Intracardiac, intravascular, two-dimensional, high-frequency ultrasound imaging of pulmonary artery and its branches in humans and animals.
复制标题
人类和动物肺动脉及其分支的心内、血管内、二维、高频超声成像。
作者：
N. Pandian;Andrew Weintraub;A. Kreis;S. Schwartz;Marvin A. Konstam;Deeb N. Salem
血管内超声成像是一种很有前途的评价血管形态的新方法。我们评估了血管内超声体外定量肺动脉（PA）形态的能力，并探讨了动物和人类体内PA成像的可行性。在15个PA段的体外研究中，我们使用了20 MHz原型超声导管。血管内超声（y）提供了PA节段的清晰图像，并在估计管腔面积时与解剖测量（x）表现出良好的相关性（y = 0.89x + 2.95，r = 0.99，p <0.001），管腔直径（n = 30，y = 0.79x + 0.96，r = 0.92，p <0.001）和血管壁厚度（n = 60，y = 0.65x + 0.33，r = 0.85，p <0.001）。随后，我们将探头引入到10只狗的PA中，并能够获得主PA、其主要分支以及远至楔水平的更小分支的实时二维图像。为了评价PA成像在清醒人体中的体内可行性，我们在22名受试者中使用了市售的20 MHz血管内超声（IVUS）导管，在标准诊断性心导管插入术结束时通过股静脉或颈静脉鞘。在20名受试者中，我们获得了近端和远端PA的动态，高分辨率，横截面图像。当IVUS导管到达分支点并通过更远端时，可以清楚地识别形状变化和管腔面积减少。无并发症。（250字处删节）
Intravascular ultrasound imaging is a promising new method for assessing vascular morphology. We evaluated the capability of intravascular ultrasound to quantify pulmonary artery (PA) morphology in vitro and explored the feasibility of in vivo PA imaging in animals and humans. In the in vitro study of 15 PA segments, we used a 20-MHz prototype ultrasound catheter. Intravascular ultrasound (y) provided crisp images of PA segments and demonstrated excellent correlations with anatomic measurements (x) in the estimation of luminal area (y = 0.89x + 2.95, r = 0.99, p less than 0.001), luminal diameter (n = 30, y = 0.79x + 0.96, r = 0.92, p less than 0.001), and vessel wall thickness (n = 60, y = 0.65x + 0.33, r = 0.85, p less than 0.001). We subsequently introduced the probe into the PA of 10 dogs and were able to obtain real-time, two-dimensional images of the main PA, its major branches, and farther smaller branches as far as the wedge level. To evaluate the in vivo feasibility of PA imaging in conscious humans, we used a commercially available, 20-MHz intravascular ultrasound (IVUS) catheter in 22 subjects through a femoral or jugular venous sheath at the end of standard diagnostic cardiac catheterization. In 20 subjects, we acquired dynamic, high-resolution, cross-sectional images of the proximal and distal PA. Changes in shape and decreasing luminal area could be clearly recognized as the IVUS catheter reached branching points and as it passed more distally. There were no complications.(ABSTRACT TRUNCATED AT 250 WORDS)