Glucose-permeable interpenetrating polymer network hydrogels for corneal implant applications: A pilot study
Glucose-permeable interpenetrating polymer network hydrogels for corneal implant applications: A pilot study
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DOI：
10.1080/02713680701793930
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发表时间：
2008-01-01
影响因子：
2
通讯作者：
Ta, Christopher N.
中科院分区：
文献类型：
--
作者：
Myung, David;Farooqui, Nabeel;Ta, Christopher N.
人工角膜的上皮化要求植入材料对葡萄糖具有足够的渗透性。我们已经开发了一种聚（乙二醇）/聚（丙烯酸）（PEG/PAA）互穿聚合物网络（IPN）水凝胶，可以提供足够的通道，葡萄糖从房水上皮细胞在体内。合成了一系列具有不同PEG大分子单体分子量的PEG/PAA IPN，并通过溶胀研究来评估其水含量和扩散实验来评估其对葡萄糖的渗透性。本研究中制备的PEG/PAA水凝胶之一具有与人角膜几乎相同的葡萄糖扩散系数（类似于2.5 × 10（-6）cm（2）/sec）。当在兔角膜中基质内植入时，该水凝胶在10例病例中的9例中保留并耐受良好，持续14天。保留的水凝胶保持光学透明，上皮保持完整和多层，表明该材料促进葡萄糖从房水转运到眼睛的前部。这些实验的结果表明，PEG/PAA水凝胶是用于角膜植入物应用如人工角膜和角膜内透镜的有希望的候选物，并且PEG/PAA IPN系统通常可用于产生用于眼科和其他生物医学应用的可渗透基底。
Epithelialization of a keratoprosthesis requires that the implant material be sufficiently permeable to glucose. We have developed a poly(ethylene glycol)/poly(acrylic acid) (PEG/PAA) interpenetrating polymer network (IPN) hydrogel that can provide adequate passage of glucose from the aqueous humor to the epithelium in vivo. A series of PEG/PAA IPNs with varying PEG macromonomer molecular weights were synthesized and evaluated through swelling studies to determine their water content and diffusion experiments to assess their permeability to glucose. One of the PEG/PAA hydrogels prepared in this study had a glucose diffusion coefficient nearly identical to that of the human cornea (similar to 2.5 10(-6) cm(2)/sec). When implanted intrastromally in rabbit corneas, this hydrogel was retained and well-tolerated in 9 out of 10 cases for a period of 14 days. The retained hydrogels stayed optically clear and the epithelium remained intact and multilayered, indicating that the material facilitated glucose transport from the aqueous humor to the anterior part of the eye. The results from these experiments indicate that PEG/PAA hydrogels are promising candidates for corneal implant applications such as keratoprostheses and intracorneal lenses, and that the PEG/PAA IPN system in general is useful for creating permeable substrates for ophthalmic and other biomedical applications.