Alarmin(g) the innate immune system to invasive fungal infections.
Alarmin(g) the innate immune system to invasive fungal infections.
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DOI：
10.1016/j.mib.2016.06.002
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发表时间：
2016-08
影响因子：
5.4
通讯作者：
Obar JJ
中科院分区：
文献类型：
--
作者：
Caffrey AK;Obar JJ
真菌在哺乳动物的宿主中遇到许多压力，包括免疫系统，它们必须适应这些压力才能生长和致病。宿主免疫系统根据入侵病原体构成的威胁程度调整其反应。我们讨论了最近的发现，即白细胞介素1信号是如何调节免疫反应的入侵真菌的毒力潜力，以及其他病原体。此外，我们还讨论了可能驱动组织侵袭和破坏的真菌因素，这些因素调节了IL-1细胞因子的释放。进一步了解真菌对宿主的适应机制，以及了解宿主固有免疫系统如何识别入侵的真菌病原体，将增加我们治疗侵袭性真菌感染的选择。
Fungi encounter numerous stresses in a mammalian host, including the immune system, which they must adapt to in order to grow and cause disease. The host immune system tunes its response to the threat level posed by the invading pathogen. We discuss recent findings on how interleukin (IL)-1 signaling is central to tuning the immune response to the virulence potential of invasive fungi, as well as other pathogens. Moreover, we discuss fungal factors that may drive tissue invasion and destruction that regulate IL-1 cytokine release. Moving forward understanding the mechanisms of fungal adaption to the host, together with understanding how the host innate immune system recognizes invading fungal pathogens will increase our therapeutic options for treatment of invasive fungal infections.