Overview on the Bacterial Iron-Riboflavin Metabolic Axis.
Overview on the Bacterial Iron-Riboflavin Metabolic Axis.
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DOI：
10.3389/fmicb.2018.01478
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发表时间：
2018
影响因子：
5.2
通讯作者：
García-Angulo VA
中科院分区：
文献类型：
--
作者：
Sepúlveda Cisternas I;Salazar JC;García-Angulo VA
氧化还原反应在生物过程中普遍存在。参与氧化还原代谢的酶通常使用辅因子以促进电子转移反应。常见的氧化还原辅因子包括微量营养素，如维生素和金属。到目前为止，铁是主要的金属辅因子，核黄素是最重要的有机辅因子。值得注意的是，铁和核黄素的代谢似乎在整个生命王国中是内在相关的。在细菌中，铁的可利用性影响核黄素生物合成基因的表达。有文献证据表明核黄素参与了某些物种的铁限制条件。这可能是通过减少细胞外铁，改善铁摄取途径和提高溶血活性来增加铁的生物利用度。在某些情况下，核黄素也可以作为酶辅因子替代铁。此外，核黄素还参与某些物种细胞外呼吸过程中异化铁的还原。本文综述了核黄素与铁在细菌生理学中的主要直接代谢关系。
Redox reactions are ubiquitous in biological processes. Enzymes involved in redox metabolism often use cofactors in order to facilitate electron-transfer reactions. Common redox cofactors include micronutrients such as vitamins and metals. By far, while iron is the main metal cofactor, riboflavin is the most important organic cofactor. Notably, the metabolism of iron and riboflavin seem to be intrinsically related across life kingdoms. In bacteria, iron availability influences expression of riboflavin biosynthetic genes. There is documented evidence for riboflavin involvement in surpassing iron-restrictive conditions in some species. This is probably achieved through increase in iron bioavailability by reduction of extracellular iron, improvement of iron uptake pathways and boosting hemolytic activity. In some cases, riboflavin may also work as replacement of iron as enzyme cofactor. In addition, riboflavin is involved in dissimilatory iron reduction during extracellular respiration by some species. The main direct metabolic relationships between riboflavin and iron in bacterial physiology are reviewed here.