Atypical fetal prostate development is associated with ipsilateral hypoplasia of the wolffian ducts in the ACI rat.
Atypical fetal prostate development is associated with ipsilateral hypoplasia of the wolffian ducts in the ACI rat.
复制标题
非典型胎儿前列腺发育与 ACI 大鼠同侧沃尔夫管发育不全有关。
DOI：
10.1002/ar.21073
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Timms,BarryG
中科院分区：
文献类型：
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作者：
Hofkamp,LukeE;Bradley,Sarahann;Geliebter,Jan;Timms,BarryG
半个多世纪以来，ACI(8月×哥本哈根)大鼠一直是研究肾发育不全和Wolffian来源结构(WDS)同侧发育不良(IHP)的主要模型。由于ACI大鼠也被用作前列腺研究的模型，因此研究IHP与尿生殖窦(UGS)发育的关系非常重要。前列腺的正常生长和分化依赖于雄激素。雄激素产生和/或输送到UGS的改变有可能扰乱正常发育。在这项研究中，我们调查了同侧WDS的丢失是否与前列腺发育改变有关。使用连续切片的胎儿ACI大鼠UGS的数字图像来创建发育中的前列腺、精囊、输精管和妊娠第21天的椭圆形的三维(3-D)表面渲染模型。根据三维模型数据计算出从UGS发育而来的前列腺导管的数量和体积。与正常雄性急性脑梗塞大鼠相比，患有IHP的动物的胎儿前列腺总体积显著减少(40%；P<；0.005)，具有显著的区域特异性差异。在IHP的动物中，也可以看到椭圆体的解剖和组织学差异，同侧睾丸的异常组织学，以及同侧Wolffian导管间充质被截断。需要更多的研究来进一步了解IHP对前列腺生长和发育的机制和后果。男性附性器官的正常产前发育的改变可能会对成人腺的生长和形态产生重要的影响。Anat Rec，2010年。©2010 Wiley-Liss公司。
For over a half century, the ACI (August × Copenhagen) rat has been a primary model for studying renal agenesis and ipsilateral hypoplasia (IHP) of the Wolffian‐derived structures (WDS). Because the ACI rat is also used as a model for prostate research, it is important to examine the relationship of IHP and urogenital sinus (UGS) development. The prostate is dependent on androgens for proper growth and differentiation. Alteration in androgen production and/or delivery to the UGS has the potential to perturbate normal development. In this study, we investigate whether the ipsilateral loss of the WDS is associated with altered prostate development. Digital images of serial‐sectioned fetal ACI rat UGS were used to create three‐dimensional (3‐D) surface‐rendered models of the developing prostate, seminal vesicle, vas deferens, and utricle on gestational day 21. The number and volume of prostate ducts developing from the UGS were calculated from the 3‐D model data. Animals exhibiting IHP had a significant decrease in total fetal prostate volume (40%;P< 0.005) with significant regional specific differences when compared with normal male ACI rats. Anatomical and histological differences in the utricle, abnormal histology of the ipsilateral testes, and a truncation of the ipsilateral Wolffian ductal mesenchyme were also seen in the animals with IHP. Additional research is needed to further understand the mechanisms and consequences of IHP on prostate growth and development. Alterations to normal prenatal development of the male accessory sex organs can have important consequences for the growth and morphology of the adult gland. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.