The molecular choreography of a store-operated calcium channel
The molecular choreography of a store-operated calcium channel
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DOI：
10.1038/nature05637
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发表时间：
2007-03-15
期刊：
影响因子：
64.8
通讯作者：
Lewis, Richard S.
中科院分区：
文献类型：
--
作者：
Lewis, Richard S.
钙库操纵的钙通道 (SOC) 具有从分泌和运动到基因表达和细胞生长的基本功能。一个根本的谜团是，内质网 (ER) 中 Ca2+ 的消耗如何激活 Ca2+ 通过质膜中的 SOC 进入。最近使用遗传方法的研究已经确定了编码 ER Ca2+ 传感器和原型 SOC（Ca2+ 释放激活 Ca2+ (CRAC) 通道）的基因。新的发现揭示了一种独特的通道激活机制，其中 CRAC 通道及其传感器独立迁移到 ER 和质膜中紧密相连的相互作用位点。
Store-operated calcium channels (SOCs) serve essential functions from secretion and motility to gene expression and cell growth. A fundamental mystery is how the depletion of Ca2+ from the endoplasmic reticulum (ER) activates Ca2+ entry through SOCs in the plasma membrane. Recent studies using genetic approaches have identified genes encoding the ER Ca2+ sensor and a prototypic SOC, the Ca2+-release-activated Ca2+ (CRAC) channel. New findings reveal a unique mechanism for channel activation, in which the CRAC channel and its sensor migrate independently to closely apposed sites of interaction in the ER and the plasma membrane.