DEVELOPMENT OF THE PRIMARY ANTIBODY REPERTOIRE

DEVELOPMENT OF THE PRIMARY ANTIBODY REPERTOIRE
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DOI:
10.1126/science.3317825
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发表时间:
1987-11-20
期刊:
影响因子:
56.9
通讯作者:
YANCOPOULOS, GD
YANCOPOULOS, GD
中科院分区:
综合性期刊1区
文献类型:
--
作者:
ALT, FW;BLACKWELL, TK;YANCOPOULOS, GD

文献摘要

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产生多种免疫反应的能力取决于编码免疫球蛋白分子抗原结合部分的基因的体细胞组装。在本文中,我们讨论了这些基因组重排事件的机制和控制,以及这一过程的各个方面如何参与产生一抗库。
The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.