DEVELOPMENT OF THE PRIMARY ANTIBODY REPERTOIRE
DEVELOPMENT OF THE PRIMARY ANTIBODY REPERTOIRE
复制标题
DOI:
10.1126/science.3317825
复制
发表时间:
1987-11-20
期刊:
影响因子:
56.9
通讯作者:
YANCOPOULOS, GD
中科院分区:
文献类型:
--
作者:
ALT, FW;BLACKWELL, TK;YANCOPOULOS, GD
The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.