FTIR study of the surface-ligand exchange reaction with glutathione on biocompatible rod-shaped CdSe/CdS semiconductor nanocrystals
FTIR study of the surface-ligand exchange reaction with glutathione on biocompatible rod-shaped CdSe/CdS semiconductor nanocrystals
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生物相容性棒状 CdSe/CdS 半导体纳米晶上谷胱甘肽表面配体交换反应的 FTIR 研究
DOI：
10.1039/d2cp00574c
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发表时间：
2022
影响因子：
3.3
通讯作者：
Fujii Fumihiko
中科院分区：
文献类型：
--
作者：
Kuroi Kunisato;Yamada Masaki;Kawamura Ibuki;Jung Minkyo;Pack Chan-Gi;Fujii Fumihiko
半导体纳米晶体（SNCs）是生命科学中必不可少的光学工具。SNCs在生命系统中的应用要求其表面覆盖有生物相容性分子。通过谷胱甘肽（GSH）对SNCs进行表面封端是制备生物相容性SNCs的有效手段，并且涉及用GSH替换初始表面配体。然而，这种配体交换反应的分子洞察力仍然难以捉摸。对这一过程的分子洞察是重要的，因为表面配体显著影响SNCs的物理性质，如稳定性和量子产率。在这项研究中，我们研究了谷胱甘肽的棒状CdSe/CdS SNCs的配体交换反应，傅里叶变换红外（FTIR）吸收光谱。阐明了GSH在SNC表面的结构和相互作用。在SNC表面上的GSH摩尔分数的定量测定表明，保留了约3%的初始三辛基氧化膦（TOPO）配体。浓度依赖性实验表明，GSH的表面摩尔分数的影响的物理性质，增溶产率，和SNCs的量子产率以线性方式。
Semiconductor nanocrystals (SNCs) are an essential optical tool in life sciences. Application of SNCs to living systems requires that their surfaces be covered with biocompatible molecules. The surface capping of SNCs by glutathione (GSH) is an effective means to prepare biocompatible SNCs and involves replacement of the initial surface ligands with GSH. However, molecular insight into such ligand-exchange reactions remains elusive. Molecular insight into this process is important, because surface ligands significantly impact physical properties such as the stability and quantum yield of SNCs. In this study, we investigate the ligand-exchange reaction of GSH on rod-shaped CdSe/CdS SNCs by Fourier-transform infrared (FTIR) absorption spectroscopy. The structure and interactions of GSH on SNC surfaces are clarified. Quantitative determination of the GSH molar fraction on SNC surfaces reveals that ∼3% of the initial trioctylphosphine oxide (TOPO) ligand is retained. Concentration-dependent experiments show that the surface molar fraction of GSH impacts the physical properties, solubilization yields, and quantum yields of SNCs in a linear manner.