The diagnostic odds ratio: a single indicator of test performance
The diagnostic odds ratio: a single indicator of test performance
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DOI：
10.1016/s0895-4356(03)00177-x
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发表时间：
2003-11-01
影响因子：
7.2
通讯作者：
Bossuyt, PMM
中科院分区：
文献类型：
--
作者：
Glas, AS;Lijmer, JG;Bossuyt, PMM
诊断测试可以用来区分患有目标疾病的受试者和没有目标疾病的受试者。已经提出了几个诊断性能的指标，例如灵敏度和特异性。使用配对指标在比较竞争测试的性能时可能是一个缺点，特别是如果一个测试在两个指标上都没有优于另一个测试。在这里，我们建议使用比值比作为诊断性能的单一指标。诊断比值比与现有指标密切相关，它有助于对诊断测试性能研究进行正式的荟萃分析，并且它来自逻辑模型，该模型允许纳入额外的变量以校正异质性。缺点是不可能分别权衡真阳性率和假阳性率。本文举例说明诊断比值比在试验评价中的应用。(C)2003年爱思唯尔公司All rights reserved.
Diagnostic testing can be used to discriminate subjects with a target disorder from subjects without it. Several indicators of diagnostic performance have been proposed, such as sensitivity and specificity. Using paired indicators can be a disadvantage in comparing the performance of competing tests, especially if one test does not outperform the other on both indicators. Here we propose the use of the odds ratio as a single indicator of diagnostic performance. The diagnostic odds ratio is closely linked to existing indicators, it facilitates formal meta-analysis of studies on diagnostic test performance, and it is derived from logistic models, which allow for the inclusion of additional variables to correct for heterogeneity. A disadvantage is the impossibility of weighing the true positive and false positive rate separately. In this article the application of the diagnostic odds ratio in test evaluation is illustrated. (C) 2003 Elsevier Inc. All rights reserved.