Comparison of Seven Staging Systems in Cirrhotic Patients With Hepatocellular Carcinoma in a Cohort of Patients Who Underwent Radiofrequency Ablation With Complete Response
Comparison of Seven Staging Systems in Cirrhotic Patients With Hepatocellular Carcinoma in a Cohort of Patients Who Underwent Radiofrequency Ablation With Complete Response
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DOI：
10.1111/j.1572-0241.2007.01604.x
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发表时间：
2008-03-01
影响因子：
9.8
通讯作者：
Iacono, Calogero
中科院分区：
文献类型：
--
作者：
Guglielmi, Alfredo;Ruzzenente, Andrea;Iacono, Calogero
背景和目标：肝细胞癌（HCC）的分期系统已经提出了许多，但最好的工具，肝癌分期仍然存在争议。本研究的目的是确定最佳的分期系统评估的预测能力，为每个七个不同的分期系统应用于一个同质组的患者谁接受经皮射频消融（RFA）。方法：我们回顾性分析了112例肝癌和肝硬化经皮射频消融治疗从1998年1月至2005年4月。通过计算机断层扫描（CT）或磁共振成像（MRI）和血清甲胎蛋白水平（AFP）评估30天后和长期随访的治疗反应。所有的112例患者进行分组，根据每一个七个不同的分期系统：Okuda，TNM，BCLC，CLIP，GRETCH，CUPI，JIS.Results：平均随访时间的112例患者提交RFA为24个月（范围3-92个月），生存率在1，3，5年的82%，40%，18%，分别。单因素和多因素分析显示，影响生存的因素有Child-Pugh评分（P
BACKGROUND AND AIMS: Many staging systems for hepatocellular carcinoma (HCC) have been proposed but the best tool for staging of HCC remains controversial. The aim of the present study was to identify the best staging system evaluating the predictive ability for outcome for each of the seven different staging systems applied in a homogeneous group of patients who underwent percutaneous radiofrequency ablation (RFA).METHODS: We analyzed retrospectively 112 patients with HCC and cirrhosis treated with percutaneous RFA from January, 1998 to April, 2005. Response to treatment after 30 days and for long-term follow-up was evaluated with computed tomography (CT) or magnetic resonance imaging (MRI) and serum alpha-fetoprotein level (AFP). All of the 112 patients were grouped according to each one of the seven different staging systems: Okuda, TNM, BCLC, CLIP, GRETCH, CUPI, JIS.RESULTS: The mean follow-up time of the 112 patients submitted to RFA was 24 months (range 3-92 months) with survival rates at 1, 3, and 5 yr of 82%, 40%, and 18%, respectively. Univariate and multivariate analyses showed that factors related to survival were Child-Pugh score (P