The origins and implications of intratumor heterogeneity.
The origins and implications of intratumor heterogeneity.
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DOI：
10.1158/1940-6207.capr-10-0234
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Polyak K
中科院分区：
文献类型：
--
作者：
Michor F;Polyak K
人类肿瘤通常在组织学、基因表达、基因型以及转移和增殖潜力等各种特征上表现出惊人的肿瘤内异质性。这种表型和遗传异质性在肿瘤形成、癌症进展和治疗耐药性中发挥着重要作用。在本期杂志中（从第 XXX 页开始），Merlo 等人。报告他们使用 239 名巴雷特食管患者的分子数据来评估主要多样性指数预测食管腺癌进展的倾向。这项工作有助于阐明分子异质性对肿瘤进化的影响。
Human tumors often display startling intratumor heterogeneity in various features including histology, gene expression, genotype, and metastatic and proliferative potential. This phenotypic and genetic heterogeneity plays an important role in neoplasia, cancer progression, and therapeutic resistance. In this issue of the journal (beginning on page XXX), Merlo et al. report their use of molecular data from 239 patients with Barrett’s esophagus to evaluate the propensity of major diversity indices for predicting progression to esophageal adenocarcinoma. This work helps elucidate the implications of molecular heterogeneity for the evolution of neoplasia.