IDENTIFICATION OF URATE CRYSTALS IN GOUTY SYNOVIAL FLUID
IDENTIFICATION OF URATE CRYSTALS IN GOUTY SYNOVIAL FLUID
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DOI：
10.7326/0003-4819-54-3-452
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发表时间：
1961-01-01
影响因子：
39.2
通讯作者：
HOLLANDER, JL
中科院分区：
文献类型：
--
作者：
MCCARTY, DJ;HOLLANDER, JL
通过偏光显微镜观察发现，滑液中的尿酸盐晶体与皮下痛风中的尿酸盐晶体具有相同的光学性质。它们在长轴上呈负双折射，消光。在15-18例临床痛风患者抽出的滑液中，用偏振光显微镜观察到尿酸盐结晶。在所有15个样本中，晶体都被尿酸酶特异性地消化，在两个例子中，对照样本中也消失了。在相同的18个滑液样本中，有11个在普通光学显微镜下也发现了尿酸盐结晶。将普通光学显微镜的结果与偏光显微镜观察的结果进行比较，发现使用偏光显微镜方法的阳性鉴定率更高。在两个例子中，晶体是用普通的光看到的，而不具有尿酸盐晶体的特征。其中一例来自一例典型的急性痛风性关节炎。急性发作期滑液中的尿酸浓度可能高于血清中的浓度。
Urate crystals in synovial fluid and the crystals from a subcutaneous tophus were found to have identical optical properties by polarized light microscopy. They were negatively birefringent with extinction on the long axis. Urate crystals were identified by polarized light microscopy in the aspirated synovial fluid obtained from 15 to 18 patients with clinical gout. The crystals were specifically digested by uricase in all 15 samples and in two instances disappeared in the control specimens as well. Urate crystals were also identified by ordinary light microscopy in 11 of the same 18 synovial fluid samples. Comparison of the results of ordinary light microscopy with those seen by polariscopic observation revealed that the percentage of positive identification was greater when the latter method was used. In two instances, crystals were seen by ordinary light which did not have the characteristics of urate crystals. One of these was from an otherwise typical case of acute gouty arthritis. The concentration of urate in the synovial fluid during the acute attack is probably higher than that found in the serum.