Ultrasound applicators with integrated catheter-cooling for interstitial hyperthermia: Theory and preliminary experiments
Ultrasound applicators with integrated catheter-cooling for interstitial hyperthermia: Theory and preliminary experiments
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DOI：
10.3109/02656739609022515
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发表时间：
1996-03-01
影响因子：
3.1
通讯作者：
Diederich, CJ
中科院分区：
文献类型：
--
作者：
Diederich, CJ
理论和实验的方法被用来评估一个设计的超声施源器间质热疗。基本方案由管状压电陶瓷辐射器（直径1.5-1.6 mm）的多元件阵列组成，每个5-10 mm长，具有单独的功率控制，设计用于插入13-14号封闭式近距离放射治疗植入导管内。用于循环温度调节水的通道集成在施用器内，以提供对导管/组织界面温度的控制。进行了定量理论分析，以确定加热性能作为施源器间距，血液灌注，导管材料，频率和所需的声功率输出的函数。原型多元素喷头的构造和特征在于声压平方分布和声功率输出能力。本研究证明了植入物内这些导管冷却多元件超声施源器的明显优势，包括在高灌注组织内可实现更高的T-90，纵向功率沉积的动态控制，相邻施源器或元件之间无相互作用或对施源器对准敏感。原型器械的初步测量结果表明，采用集成导管冷却的组织间超声施源器是可行的，但需要进一步开发和体内性能验证。
Theoretical and experimental methods were used to evaluate a design of ultrasound applicators for interstitial hyperthermia. The basic schema consists of a multielement array of tubular piezoceramic radiators (1.5-1.6 mm diameter), each 5-10 mm long with separate power control, designed to be inserted within a 13-14 gauge closed-end brachytherapy implant catheter. Channels for circulating temperature-regulated water are integrated within the applicator to provide control of the catheter/tissue interface temperature. A quantitative theoretical analysis was undertaken to determine heating performance as a function of applicator spacing, blood perfusion, catheter material, frequency and required acoustic power output. Prototype multielement applicators were constructed and characterized in terms of acoustic pressure-squared distributions and acoustic power output capabilities. This study demonstrated distinct advantages of these catheter-cooled multielement ultrasound applicators within an implant, including higher T-90's achievable within highly perfused tissues, dynamic control of the longitudinal power deposition, and no interaction between adjacent applicators or elements or sensitivity to applicator alignment. Preliminary measurements of prototype devices have indicated that implementation of these interstitial ultrasound applicators with integrated catheter-cooling is practicable, yet further development and in vivo verification of performance is warranted.