Characterization of macular edema from various etiologies by optical coherence tomography
Characterization of macular edema from various etiologies by optical coherence tomography
复制标题
通过光学相干断层扫描鉴别不同病因引起的黄斑水肿
DOI：
10.1016/j.ajo.2005.02.053
复制
发表时间：
2005-08-01
影响因子：
4.2
通讯作者：
Massin, P
中科院分区：
文献类型：
--
作者：
Catier, A;Tadayoni, R;Massin, P
目的：采用光学相干断层扫描（OCT），以表征视网膜内的变化与黄斑水肿（ME），根据其病因。设计：观察病例series.Methods：78眼ME患者进行了回顾性OCT检查，使用Humphrey 2000 OCT系统（Humphrey公司，圣莱安德罗，加州）。ME病因为糖尿病视网膜病变（27例）、视网膜中央静脉阻塞（18例）、人工晶状体（15例）、后葡萄膜炎（10例）和视网膜色素变性（8例）。使用OCT标测软件测量黄斑厚度。结果：78例中，72例（92%）ME位于视网膜外层。浆液性视网膜脱离29例（37%）。视网膜中央静脉阻塞最常见（10/18例，56%）。无论浆液性视网膜脱离是否合并ME，视力（P= 0.26）或黄斑厚度（P= 0.95）均无显著差异。78例病例中有17例（22%）后玻璃体部分脱离。浆液性视网膜脱离与部分后玻璃体脱离无关（P=.6）。平均黄斑厚度从视网膜中央静脉阻塞的506 μ m到视网膜色素变性的373 μ m不等。在糖尿病视网膜病变组（R=0.55; P= 0.0027）和人工晶状体组（R=0.66; P= 0.016）中，视力与黄斑厚度相关。结论：OCT可表征ME相关的视网膜形态学改变，尤其是玻璃体黄斑关系和亚临床浆液性黄斑脱离。这种脱离与视力差无关。黄斑增厚仅与糖尿病视网膜病变和人工晶状体眼的视力丧失相关。
Purpose: To use optical coherence tomography (OCT) to characterize the intraretinal changes associated with macular edema (ME) according to its etiology.Design: Observational case series.Methods: Seventy-eight eyes of 78 patients with ME were examined retrospectively by OCT, using the Humphrey 2000 OCT system (Humphrey Co., San Leandro, California). ME etiologies were diabetic retinopathy (27 cases), central retinal vein occlusion (18 cases), pseudophakia (15 cases), posterior uveitis (10 cases), and retinitis pigmentosa (eight cases). Macular thickness was measured using OCT mapping software. It was correlated with logarithmic visual acuity.Results: In 72 of 78 cases (92%), ME was located in the outer retinal layers. Serous retinal detachment was present in 29 of 78 cases (37%). It was most frequent in central retinal vein occlusion (10 of 18 cases, 56%). There were no significant differences in visual acuity (P=.26) or macular thickness (P=.95) whether or not serous retinal detachment was combined with ME. The posterior hyaloid was partially detached in 17 of 78 cases (22%) of overall cases. Serous retinal detachment did not correlate with partial posterior hyaloid detachment (P=.6). Mean macular thickness ranged from 506 mu m in central retinal vein occlusion to 373 mu m in retinitis pigmentosa. Visual acuity correlated with macular thickness in diabetic retinopathy (R=0.55; P=.0027) and pseudophakia cases (R=0.66; P=.016).Conclusions: OCT characterized the retinal morphologic changes associated with ME, especially the vitreomacular relationship and sub-clinical serous macular detachment. This detachment did not correlate with poor visual acuity. Macular thickening only correlated with visual loss in diabetic retinopathy and pseudophakia.