Influence of eye position on activity in monkey superior colliculus.
Influence of eye position on activity in monkey superior colliculus.
复制标题
眼位对猴上丘活动的影响。
DOI：
10.1152/jn.1995.74.4.1593
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发表时间：
1995
影响因子：
2.5
通讯作者：
V. Henn
中科院分区：
文献类型：
--
作者：
A. Opstal;K. Hepp;Y. Suzuki;V. Henn
1.迄今为止，关于猴上级丘（SC）在眼动产生中的作用的大多数记录研究表明，招募的细胞群体的代码是代表期望的扫视眼位移矢量的固定矢量命令，而与眼睛在眼眶中的位置无关。然而，来自微刺激、病变和神经解剖学的实验证据表明，SC可以获得眼睛位置信号。2.在本文中，我们已经测试了这一假设，SC活动的影响，眼睛的位置，记录从preaccadic爆发神经元，而猴子的快速眼球运动的光覆盖了大部分的oculabular范围。3.在四个警觉的恒河猴，我们获得了足够的数据，从57 SC单单位。这些细胞中的相当一部分（30/57）的活性似乎受到眼睛位置的显著影响。虽然这些细胞的扫视幅度和方向的调谐性能保持不变的眼睛位置的变化，这些单位的峰值放电率系统的影响，在头部的眼睛的位置。4.我们的特点是这种眼睛的位置依赖的神经元的活动由一个定性的，模型无关的，以及由一个定量的模型描述（增益场），它考虑到了两个调谐性能的细胞的眼睛位移矢量和眼睛的位置的依赖。5.尽管大多数增益场使它们的眼睛位置灵敏度矢量与最佳扫视矢量方向大致对准（共线增益场，17/30），但是增益场的实质部分使它们的眼睛位置灵敏度矢量在相当不同的方向上，相对于单元的ON方向近似均匀地分布。6.我们的结论是，SC可以获得与眼睛在眼眶中的位置相关的信号。几个假设可能的功能作用，这个信号，在有关的神经代码的运动地图，进行了讨论。
1. Most recording studies on the role of the monkey superior colliculus (SC) in eye movement generation have so far indicated that the code of the recruited population of cells is a fixed vector command representing the desired saccadic eye displacement vector, irrespective of the position of the eyes in the orbit. Experimental evidence from microstimulation, lesions, and neuroanatomy, however, suggests that the SC may have access to an eye position signal. 2. In this paper we have tested the hypothesis that SC activity is influenced by eye position, by recording from presaccadic burst neurons while monkeys made rapid eye movements in the light covering a large part of the oculomotor range. 3. In four alert rhesus monkeys, we obtained sufficient data from 57 SC single units. The activity of a substantial part of these cells (30/57) appeared to be significantly influenced by eye position. Although the tuning properties of these cells for saccade amplitude and direction remained invariant for changes in eye position, the peak firing rate of these units was systematically influenced by the position of the eyes in the head. 4. We have characterized this eye position dependence of a neuron's activity by a qualitative, model-independent, as well as by a quantitative model description (gain field), which takes into account both the tuning properties of the cell for eye displacement vectors and the dependence of eye position. 5. Although a majority of gain fields had their eye position sensitivity vector roughly aligned with the optimal saccade vector direction (colinear gain field, 17/30), a substantial part of the gain fields had their eye position sensitivity vectors in quite different directions, approximately homogeneously distributed with respect to the cell's ON direction. 6. We conclude that the SC has access to a signal related to the position of the eyes in the orbit. Several hypotheses on the possible functional role of this signal, in relation to the neural code of the motor map, are discussed.