Raised intracranial pressure increases CSF drainage through arachnoid villi and extracranial lymphatics
Raised intracranial pressure increases CSF drainage through arachnoid villi and extracranial lymphatics
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DOI：
10.1152/ajpregu.1998.275.3.r889
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发表时间：
1998-09-01
影响因子：
2.8
通讯作者：
Johnston, M
中科院分区：
文献类型：
--
作者：
Boulton, M;Armstrong, D;Johnston, M
我们之前证明，从颅顶取出的脑脊液（CSF）大约有一半是通过颅外淋巴管清除的。在本报告中，我们检验了这样的假设：随着麻醉羊颅内压 (ICP) 的升高，脑脊液的淋巴引流也会增加。将导管插入双侧侧脑室、小脑延髓池、颈淋巴管和颈静脉。采用脑室灌注系统来调节脑脊液压力并将蛋白质示踪剂（I-125 标记的人血清白蛋白）输送到脑脊液室中。静脉注射 I-131 标记的人血清白蛋白，以计算血浆示踪剂损失和示踪剂再循环进入淋巴管。通过适当调节流入储液器和小脑池流出导管的高度来控制ICP。实验设计包括对同一动物进行 3 小时的低压阶段，然后是 3 小时的高压阶段（10-20 或 20-30 cmH(2)O）。我们确定，在所有八只测试的动物中，ICP 的增量变化与通过淋巴和蛛网膜绒毛途径的脑脊液转运增加相关（P = 0.004）。
We demonstrated previously that about one-half of cerebrospinal fluid (CSF) removed from the cranial vault was cleared by extracranial lymphatic vessels. In this report we test the hypothesis that lymphatic drainage of CSF increases as intracranial pressure (ICP) is elevated in anesthetized sheep. Catheters were inserted into both lateral ventricles, cisterna magna, cervical lymphatics, and jugular vein. A ventriculocisternal perfusion system was employed to regulate CSF pressures and to deliver a protein tracer (I-125-labeled human serum albumin) into the CSF compartment. I-131-labeled human serum albumin was injected intravenously to permit calculation of plasma tracer loss and tracer recirculation into lymphatics. ICP was controlled by adjusting the height of the inflow reservoir and the cisterna magna outflow catheter appropriately. The experimental design consisted of a 3-h period of lower pressure followed by a 3-h period of higher pressure in the same animal (10-20 or 20-30 cmH(2)O). We determined that incremental changes in ICP were associated with higher CSF transport through lymphatic and arachnoid villi routes in all eight animals tested (P = 0.004).