Isoflurane can indirectly depress lumbar dorsal horn activity in the goat via action within the brain.
Isoflurane can indirectly depress lumbar dorsal horn activity in the goat via action within the brain.
复制标题
异氟醚可以通过大脑内的作用间接抑制山羊腰背角的活动。
DOI：
10.1093/bja/82.2.244
复制
发表时间：
1999
影响因子：
9.8
通讯作者：
Simons,C
中科院分区：
文献类型：
--
作者：
Jinks,S;Antognini,JF;Carstens,E;Buzin,V;Simons,C
我们已经研究了腰背角细胞的反应过程中的差异异氟醚传递到山羊的大脑和脊髓的有害的机械刺激。我们假设，异氟烷，在大脑中发挥作用，会抑制背角神经元的反应，施加到后肢的有害机械刺激。用异氟烷麻醉8只山羊，进行颈部解剖，允许颅骨分流。进行腰椎椎板切除术以测量单个单位背角神经元的活动。在旁路手术前给予1.3%异氟烷，在差异给药期间，以以下头部/躯干组合给予：1.3%/1.3%、0.8%/1.3%、0.3%/1.3%、1.3%/0.8%、0.8%/0.8%和0.3%/0.8%。当躯干异氟醚浓度为1.3%时，将颅侧异氟醚从1.3%降至0.3%并没有显著影响背角反应（从平均325（SD 262）至379（412）个脉冲min-1; P < 0.05）。然而，当躯干异氟醚为0.8%时，将颅侧异氟醚从1.3%降至0.3%，平均诱发背角活动增加42%（388（359）至551（452）个脉冲min-1; P < 0.05）。这些数据表明，异氟烷对背角反应的伤害性刺激的主要影响是直接的，但也有一个间接的影响发生通过从脊髓上区域的下行预测。
We have examined the response of lumbar dorsal horn cells to a noxious mechanical stimulus during differential delivery of isoflurane to the brain and spinal cord of goats. We hypothesized that isoflurane, acting in the brain, would depress dorsal horn neuronal responses to a noxious mechanical stimulus applied to the hindlimb. Eight goats were anaesthetized with isoflurane and neck dissections performed which allowed cranial bypass. Lumbar laminectomies were performed to allow measurements of single-unit dorsal horn neuronal activity. Isoflurane 1.3% was administered before bypass, and during differential delivery it was administered at each of the following head/torso combinations: 1.3%/1.3%, 0.8%/1.3%, 0.3%/1.3%, 1.3%/0.8%, 0.8%/0.8% and 0.3%/0.8%. When the torso isoflurane concentration was 1.3%, decreasing cranial isoflurane from 1.3% to 0.3% did not significantly affect dorsal horn responses (from mean 325 (SD 262) to 379 (412) impulses min-1; P < 0.05). However, when torso isoflurane was 0.8%, decreasing cranial isoflurane from 1.3% to 0.3% increased mean evoked dorsal horn activity by 42% (388 (359) to 551 (452) impulses min-1; P < 0.05). These data suggest that the major effect of isoflurane on dorsal horn responses to noxious stimuli is direct, but there is an indirect effect occurring via descending projections from supraspinal regions.