Construction of PEG-based amphiphilic brush polymers bearing hydrophobic poly(lactic acid) side chains via successive RAFT polymerization and ROP
Construction of PEG-based amphiphilic brush polymers bearing hydrophobic poly(lactic acid) side chains via successive RAFT polymerization and ROP
复制标题
通过连续 RAFT 聚合和 ROP 构建带有疏水性聚乳酸侧链的基于 PEG 的两亲性刷状聚合物
DOI：
10.1039/c6py00189k
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发表时间：
2016-01-01
影响因子：
4.6
通讯作者：
Huang, Xiaoyu
中科院分区：
文献类型：
--
作者：
Qian, Wenhao;Song, Xuemei;Huang, Xiaoyu
采用可逆加成-断裂链转移（RAFT）聚合、开环聚合和接枝自聚合策略，合成了一系列结构明确的两亲性刷状聚合物，其中含有亲水性聚乙二醇（PEG）和疏水性聚乳酸（PLA）链段。首先使用基于PEG的链转移剂使含有ROP引发基团（-OH）的2-（（4-羟基丁酰氧基）甲基）丙烯酸叔丁酯（tBHBMA）单体进行RAFT嵌段共聚，以形成两种定义明确的PEG-b-PtBHBMA二嵌段共聚物（M-w/M-n
A series of well-defined amphiphilic brush polymers containing hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid) segments was synthesized by the combination of reversible addition-fragmentation chain transfer (RAFT) polymerization, ring opening polymerization (ROP), and the graftingfrom strategy. tert-Butyl 2-((4-hydroxybutanoyloxy)methyl)acrylate (tBHBMA) monomer containing a ROP initiation group (-OH) was first RAFT block copolymerized using a PEG-based chain transfer agent to form two well-defined PEG-b-PtBHBMA diblock copolymers (M-w/M-n