The effect of microsaccades on the correlation between neural activity and behavior in middle temporal, ventral intraparietal, and lateral intraparietal areas.
The effect of microsaccades on the correlation between neural activity and behavior in middle temporal, ventral intraparietal, and lateral intraparietal areas.
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DOI：
10.1523/jneurosci.4412-08.2009
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发表时间：
2009-05-06
期刊：
影响因子：
--
通讯作者：
Cook EP
中科院分区：
文献类型：
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作者：
Herrington TM;Masse NY;Hachmeh KJ;Smith JE;Assad JA;Cook EP
据广泛报道，视皮层中单个神经元的活动与受试者的知觉决策有关。这种相关性的强度对产生这种感觉的神经元群体有一定的影响。在这里，我们问的是微眼跳，这是一种微小的、非自愿的眼球运动，是否有助于神经活动和行为之间的相关性。我们分析了三个不同的视觉检测实验的数据，这些实验使用了来自颞中(MT)、外侧顶内(LIP)和腹侧顶内(VIP)区域的神经记录。所有三个实验都使用了随机的点运动刺激，要求动物检测运动速度或强度的瞬时或持续变化。我们发现，微眼跳抑制了神经活动，抑制了对运动刺激的检测，有助于神经活动与检测行为之间的相关性。微扫视在MT区、LIP区和VIP区的相关性中分别占19%、21%和17%。虽然微眼跳只解释了神经活动和行为之间的部分相关性，但当考虑到作为知觉决定基础的神经元群体时，它们的影响就有了意义。
It is widely reported that the activity of single neurons in visual cortex is correlated with the perceptual decision of the subject. The strength of this correlation has implications for the neuronal populations generating the percepts. Here we asked whether microsaccades, which are small, involuntary eye movements, contribute to the correlation between neural activity and behavior. We analyzed data from three different visual detection experiments, with neural recordings from the middle temporal (MT), lateral intraparietal (LIP), and ventral intraparietal (VIP) areas. All three experiments used random dot motion stimuli, with the animals required to detect a transient or sustained change in the speed or strength of motion. We found that microsaccades suppressed neural activity and inhibited detection of the motion stimulus, contributing to the correlation between neural activity and detection behavior. Microsaccades accounted for as much as 19% of the correlation for area MT, 21% for area LIP, and 17% for VIP. While microsaccades only explain part of the correlation between neural activity and behavior, their effect has implications when considering the neuronal populations underlying perceptual decisions.