The effects of 10 Hz repetitive transcranial magnetic stimulation on resting EEG power spectrum in healthy subjects
The effects of 10 Hz repetitive transcranial magnetic stimulation on resting EEG power spectrum in healthy subjects
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DOI：
10.1016/j.neulet.2007.04.030
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发表时间：
2007-05-29
影响因子：
2.5
通讯作者：
Hoeppner, Jacqueline
中科院分区：
文献类型：
--
作者：
Griskova, Inga;Ruksenas, Osvaldas;Hoeppner, Jacqueline
10Hz rTMS可能对抑郁症的治疗有一定的临床意义。然而，10Hz rTMS应用于潜在有效剂量对脑电图活动的影响还没有得到很好的研究。使用EEG，我们的目的是调查的神经生物学效应的10 Hz rTMS参数集目前用于抑郁症治疗的健康受试者的样本。在18名健康受试者中，以交叉设计给予10 Hz真实的rTMS或假刺激。真实的rTMS刺激在左背外侧前额叶皮层上以运动阈值（MT）的110%的强度进行。对于假手术条件，线圈在顶颞位置上成角度，强度降低至MT的90%。在单次rTMS会话之前和之后进行EEG记录。采用复解调法提取脑电功率谱，并对功率变化进行统计学分析。真实的10 Hz rTMS诱导Δ功率总体增加。这种增加在整个样本中普遍存在，而对α、β和θ EEG频带的功率的影响是高度可变的。假刺激对脑电功率谱没有实质性影响。此外，未检测到EEG不对称性的变化。真实的10 Hz rTMS在2000次刺激和110%强度下应用可引起健康受试者静息EEG的显著变化。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
10Hz rTMS over the left prefrontal cortex maybe useful in the treatment of depressive disorders. However, the effects of 10Hz rTMS applied in potentially effective doses on electroencephaloaraphic activity are not well studied. Using EEG, we aimed to investigate the neurobiological effects of the 10 Hz rTMS set of parameters currently used for depression treatment in a sample of healthy subjects. In 18 healthy subjects, either 10 Hz real rTMS or sham stimulation were given in a crossover design. Real rTMS stimulation was carried out with an intensity of 110% of motor threshold (MT) over the left dorsolateral prefrontal cortex. For the sham condition, the coil was angled over a parietotemporal position and the intensity was reduced to 90% of MT. EEG recordings were taken before and after a single rTMS session. EEG power spectrum was extracted using the complex demodulation method and changes in power were evaluated statistically. Real 10 Hz rTMS induced an overall increase in delta power. This increase prevailed throughout the sample, whereas effects on the power of the alpha, beta and theta EEG bands were highly variable. Sham stimulation had no substantial effects on the EEG power spectrum. Furthermore, no changes in EEG asymmetry were detected. Real 10 Hz rTMS applied at 2000 stimuli and 110% intensity may induce significant changes in resting EEG in healthy subjects. (c) 2007 Elsevier Ireland Ltd. All rights reserved.