How the Protein Data Bank changed biology: An introduction to the JBC Reviews thematic series, part 1.
How the Protein Data Bank changed biology: An introduction to the JBC Reviews thematic series, part 1.
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DOI：
10.1016/j.jbc.2021.100608
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Gierasch LM
中科院分区：
文献类型：
--
作者：
Berman HM;Gierasch LM
本文章集旨在庆祝蛋白质数据库 (PDB) 成立 50 周年，该数据库是生物大分子结构的单一全球数字档案库。 PDB 的影响是巨大的；我们邀请了一些结构生物学领域的顶尖研究人员来说明其对一系列科学领域的影响。由此呈现出一幅令人信服的图景，展示了 PDB 与许多科学领域所见证的爆炸性进展之间的协同作用。可靠、可公开访问、存档良好的结构信息的可用性可以说对细胞和分子生物学的影响甚至比 PCR 等一些支持技术更大。我们见证了科学的发展，从结构生物学家向 PDB 贡献大部分结构并供其社区内讨论的时代，到任何深入理解生化或细胞生物学问题的努力都需要建立在结构基础之上的跨学科方法。
This collection of articles celebrates the 50th anniversary of the Protein Data Bank (PDB), the single global digital archive of biological macromolecular structures. The impact of the PDB is immense; we have invited a number of top researchers in structural biology to illustrate its influence on an array of scientific fields. What emerges is a compelling picture of the synergism between the PDB and the explosive progress witnessed in many scientific areas. Availability of reliable, openly accessible, well-archived structural information has arguably had more impact on cell and molecular biology than even some of the enabling technologies such as PCR. We have seen the science move from a time when structural biologists contributed the lion’s share of the structures to the PDB and for discussion within their community to a time when any effort to achieve in-depth understanding of a biochemical or cell biological question demands an interdisciplinary approach built atop structural underpinnings.
DOI：
10.1016/j.jbc.2021.100557
发表时间：
2021-01
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Li F;Egea PF;Vecchio AJ;Asial I;Gupta M;Paulino J;Bajaj R;Dickinson MS;Ferguson-Miller S;Monk BC;Stroud RM
通讯作者：
Stroud RM
影响因子：
64.8
作者：
Senior, Andrew W.;Evans, Richard;Hassabis, Demis
通讯作者：
Hassabis, Demis