Chronic kidney disease: global dimension and perspectives
Chronic kidney disease: global dimension and perspectives
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DOI：
10.1016/s0140-6736(13)60687-x
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发表时间：
2013-07-20
期刊：
影响因子：
168.9
通讯作者：
Yang, Chih-Wei
中科院分区：
文献类型：
--
作者：
Jha, Vivekanand;Garcia-Garcia, Guillermo;Yang, Chih-Wei
慢性肾脏疾病被定义为肾小球滤过率降低，尿白蛋白排泄增加，或两者兼而有之，是一个日益严重的公共卫生问题。全球患病率估计为8-16%。并发症包括全因死亡率和心血管死亡率增加、肾脏疾病进展、急性肾损伤、认知能力下降、贫血、矿物质和骨骼疾病以及骨折。在世界范围内，糖尿病是慢性肾脏疾病最常见的原因，但在一些地区，其他原因，如草药和环境毒素，更常见。最贫困人口面临的风险最高。筛查和干预可以预防慢性肾脏疾病，并且在实施管理策略的地方，终末期肾脏疾病的发病率已经降低。然而，在许多社区和许多医生中，对这种疾病的认识仍然很低。必须将减少与慢性肾脏疾病有关的负担和费用的战略纳入国家非传染性疾病方案。
Chronic kidney disease is defined as a reduced glomerular filtration rate, increased urinary albumin excretion, or both, and is an increasing public health issue. Prevalence is estimated to be 8-16% worldwide. Complications include increased all-cause and cardiovascular mortality, kidney-disease progression, acute kidney injury, cognitive decline, anaemia, mineral and bone disorders, and fractures. Worldwide, diabetes mellitus is the most common cause of chronic kidney disease, but in some regions other causes, such as herbal and environmental toxins, are more common. The poorest populations are at the highest risk. Screening and intervention can prevent chronic kidney disease, and where management strategies have been implemented the incidence of end-stage kidney disease has been reduced. Awareness of the disorder, however, remains low in many communities and among many physicians. Strategies to reduce burden and costs related to chronic kidney disease need to be included in national programmes for non-communicable diseases.