Increased frequency of circulating Th22 cells in patients with B-cell non-Hodgkin's lymphoma.
Increased frequency of circulating Th22 cells in patients with B-cell non-Hodgkin's lymphoma.
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B 细胞非霍奇金淋巴瘤患者循环 Th22 细胞频率增加
DOI：
10.18632/oncotarget.10966
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发表时间：
2016-08-30
期刊：
影响因子：
--
通讯作者：
Ji C
中科院分区：
文献类型：
--
作者：
Lu T;Liu Y;Yu S;Yin C;Li P;Ye J;Ma D;Ji C
辅助性T（Th）22细胞在自身免疫性疾病和炎症性疾病的发病机制中起重要作用，并且其在肿瘤中的功能仍不清楚。本研究旨在探讨B细胞非霍奇金淋巴瘤（B-NHL）患者外周血Th 22细胞的变化及其临床意义。发现初治B-NHL患者外周血Th 22细胞频率明显升高，化疗后恢复正常。与Th 22频率增加一致，B-NHL患者血浆IL-22和IL-6水平显著升高。此外，增加的Th 22频率与年龄较大（> 60岁）和B-NHL患者对治疗的反应较差相关。此外，B-NHL患者外周血Th 22和Th 17细胞频率之间存在统计学正相关。本研究结果表明，Th 22细胞在B-NHL患者中的表达频率与B-NHL的临床结局和预后有关，提示Th 22细胞免疫应答在B-NHL的发生、发展中可能起重要作用。
T helper (Th) 22 cells play important roles in the pathogenesis of autoimmune and inflammatory diseases, and their function in tumors remains uncertain. In the current study, we investigated the alternations and clinical significance of circulating Th22 cells in patients with B-cell non-Hodgkin's lymphoma (B-NHL). We found that the frequency of Th22 cells was significantly elevated in peripheral blood of newly-diagnosed B-NHL patients, and returned to normal level after chemotherapy. In consistent with increased Th22 frequency, plasma IL-22 and IL-6 levels in B-NHL patients were remarkably increased. Moreover, the increased Th22 frequency was associated with the older age (> 60 yr) and a poorer response to therapy in B-NHL patients. In addition, there existed a statistically positive correlation between circulating Th22 and Th17 frequencies in B-NHL patients. Our data demonstrated that circulating Th22 frequency was associated with the clinical outcome and prognosis of B-NHL patients, indicating that Th22 immune response might play an important role in the development and progression of B-NHL.