Relationship between coronary artery remodeling and plaque vulnerability
Relationship between coronary artery remodeling and plaque vulnerability
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DOI：
10.1161/hc0802.104327
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发表时间：
2002-02-26
期刊：
影响因子：
37.8
通讯作者：
Davies, MJ
中科院分区：
文献类型：
--
作者：
Varnava, AM;Mills, PG;Davies, MJ
背景-血管内超声的体内研究表明，斑块解剖结构复杂和斑块破裂在明显的向外重构的情况下更常见。大的脂质核和高的巨噬细胞计数是斑块易损性的公认组织学标志。斑块的脆弱性，这些标志物和重塑冠状动脉之间的联系还没有explored.Methods和Results-In 88例男性受试者突然死于冠状动脉疾病，108斑块进行了研究。计算重塑百分比。重塑大于或等于0%的病变被认为是正性重塑，重塑大于或等于0%的病变被认为是正性重塑，重塑大于或等于0%的病变被认为是正性重塑。
Background-In vivo studies with intravascular ultrasound have shown that complex plaque anatomy and plaque rupture are more frequent in the presence of marked outward remodeling. A large lipid core and a high macrophage count are recognized histological markers for plaque vulnerability. The link between plaque vulnerability in terms of these markers and remodeling in coronary arteries has not been explored.Methods and Results-In 88 male subjects who died suddenly with coronary artery disease, 108 plaques were studied. The percent remodeling was calculated. Lesions with remodeling greater than or equal to0% were considered to have positive remodeling, and those in which remodeling was