PRIMARY TISSUE VALVE DEGENERATION IN GLUTARALDEHYDE-PRESERVED PORCINE BIOPROSTHESES - HANCOCK-I VERSUS CARPENTIER-EDWARDS AT 4-YEAR TO 7-YEAR FOLLOW-UP
PRIMARY TISSUE VALVE DEGENERATION IN GLUTARALDEHYDE-PRESERVED PORCINE BIOPROSTHESES - HANCOCK-I VERSUS CARPENTIER-EDWARDS AT 4-YEAR TO 7-YEAR FOLLOW-UP
复制标题
DOI：
10.1016/s0003-4975(10)60586-3
复制
发表时间：
1986-11-01
影响因子：
4.6
通讯作者：
GALLO, I
中科院分区：
文献类型：
--
作者：
NISTAL, F;ARTINANO, E;GALLO, I
在1978年4月至1980年12月的32个月期间，292名患者被分为两个相等的组，接受了汉考克或Carpentier-Edwards（CE）. sbd.戊二醛猪生物瓣膜作为二尖瓣替代物。在此期间接受二尖瓣猪异种移植物的每例患者均被纳入研究。生物瓣膜的类型始终由外科医生选择，而不是随机选择。术前临床特征、相关外科手术、瓣膜植入尺寸和随访数据显示两组之间无相关差异。汉考克组有3例原发性组织衰竭，CE组有6例（线性化发生率分别为0.49和0.97例患者/年事件百分比）。两组瓣膜关闭的平均持续时间和显微镜检查结果相似。两组中40岁以下患者的原发性组织衰竭更常见，但差异无统计学意义。与汉考克组相比，CE组中40岁及以上患者的组织衰竭发生率略高。无原发性组织衰竭的生物假体的精算生存率为6.5年/95 . ±-. 3%（平均值±）。标准误差）和84 . ±. 9%（p = NS）。两种最常用的戊二醛猪生物瓣膜之间在耐久性方面没有发现显著差异，尽管应在一项患者数量更多且随访时间更长的研究中重新评估CE在40岁以上患者中的表现。
In the 32-month period between April, 1978, and December, 1980, 292 patients, divided into two equal groups, received a glutaraldehyde porcine bioprothesis.sbd.either Hancock or Carpentier-Edwards (CE).sbd.as mitral valve substitute. Every patient receiving a mitral porcine xenograft during that time was included in the study. The type of bioprosthesis was always selected by the surgeon and not randomly. Preoparative clinical characteristics, associated surgical procedures, valve implantation size, and follow-up data showed no relevant differences between the two groups. There were three instances of primary tissue failure in the Hancock group and six in the CE (linearized rate of 0.49 and 0.97 events percentage of patient/years, respectively). Mean duration of explanted valves and microscopic findings were similar in both groups. Primary tissue failure was more frequent in patients under 40 years of age in both groups, although differences were not statistically significant. A marginally significant trend toward greater incidence of tissue failure in patients of 40 years of age and older was seen in the CE group when compared with the Hancock group. Actuarial survival of the bioprostheses free from primary tissue failure was 6.5 year of 95 .+-. 3% (mean .+-. standard error) for Hancock and 84 .+-. 9% for CE (p = NS). No significant difference in terms of durability has been found between the two most popular glutaraldehyde porcine bioprostheses, although the behavior of the CE in patients older than 40 years should be reassessed in a study with a larger number of patients and a longer follow-up period.