Detection of rheumatoid arthritis by evaluation of normalized variances of fluorescence time correlation functions
Detection of rheumatoid arthritis by evaluation of normalized variances of fluorescence time correlation functions
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DOI：
10.1117/1.3599958
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发表时间：
2011-07-01
影响因子：
3.5
通讯作者：
Osele, Ilka
中科院分区：
文献类型：
--
作者：
Dziekan, Thomas;Weissbach, Carmen;Osele, Ilka
在一项用于检测类风湿关节炎的前瞻性临床研究中，研究了使用染料吲哚菁绿色作为造影剂的荧光成像。对描述某些感兴趣区域中造影剂的团注动力学的荧光强度的相关时间序列的归一化方差进行分析，以区分健康与发炎的指关节。这些值是使用鲁棒的、无参数的算法确定的。我们发现，相关函数的归一化方差提高了志愿者的健康关节和患有类风湿性关节炎的患者的关节之间的区分，与e.例如，在一个实施例中，原始数据曲线下面积的比值。(C)2011年，美国光电仪器工程师学会（SPIE）。[DOI：10.1117/1.3599958]
Fluorescence imaging using the dye indocyanine green as a contrast agent was investigated in a prospective clinical study for the detection of rheumatoid arthritis. Normalized variances of correlated time series of fluorescence intensities describing the bolus kinetics of the contrast agent in certain regions of interest were analyzed to differentiate healthy from inflamed finger joints. These values are determined using a robust, parameter-free algorithm. We found that the normalized variance of correlation functions improves the differentiation between healthy joints of volunteers and joints with rheumatoid arthritis of patients by about 10% compared to, e. g., ratios of areas under the curves of raw data. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3599958]