Selective programming of CCR10(+) innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation.
Selective programming of CCR10(+) innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation.
复制标题
皮肤淋巴结淋巴结中CCR10（+）先天淋巴样细胞的选择性编程，以进行皮肤稳态调节。
DOI：
10.1038/ni.3312
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发表时间：
2016-01
影响因子：
30.5
通讯作者：
Xiong N
中科院分区：
文献类型：
--
作者：
Yang J;Hu S;Zhao L;Kaplan DH;Perdew GH;Xiong N
先天淋巴样细胞 (ILC) 优先定位于屏障组织，发挥组织保护作用，但也可能导致炎症性疾病。调节屏障组织中 ILC 建立的机制尚不清楚。在这里，我们表明，在稳态条件下，皮肤引流淋巴结 (sLN) 中的 ILC 被持续激活，以获得趋化因子受体 CCR10 的调节特性和高表达，从而定位到皮肤中。 CCR10+ ILC 促进皮肤驻留 T 细胞的稳态，相反，它们在皮肤中的建立需要 T 细胞调节的稳态环境。正确生成 CCR10+ ILC 需要表达 Foxn1 的 CD207+ 树突状细胞。这些观察结果揭示了 sLN 中皮肤归巢 CCR10+ ILC 的特定编程和启动的机制。
Innate lymphoid cells (ILCs) are preferentially localized into barrier tissues where they function in tissue protection but can also contribute to inflammatory diseases. The mechanisms regulating the establishment of ILCs in barrier tissues are poorly understood. Here we show that under steady-state conditions ILCs in skin-draining lymph nodes (sLNs) were continuously activated to acquire regulatory properties and high expression of the chemokine receptor CCR10 for localization into the skin. CCR10+ ILCs promoted the homeostasis of skin-resident T cells and reciprocally, their establishment in the skin required T cell-regulated homeostatic environments. Foxn1-expressing CD207+ dendritic cells were required for the proper generation of CCR10+ ILCs. These observations reveal mechanisms underlying the specific programming and priming of skin-homing CCR10+ ILCs in the sLNs.