Histology of the Cochlear Outer Sulcus Cells in Normal Human Ears, Presbycusis, and Meniere's Disease
Histology of the Cochlear Outer Sulcus Cells in Normal Human Ears, Presbycusis, and Meniere's Disease
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DOI：
10.1097/mao.0000000000002535
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发表时间：
2020-04-01
影响因子：
2.1
通讯作者：
Gluth, Michael B.
中科院分区：
文献类型：
--
作者：
Christov, Florian;Nelson, Erik G.;Gluth, Michael B.
Hypothesis:Outer sulcus cell features and distribution are hypothesized to differ throughout regions of the human cochlea and between diseased and normal specimens.Background:Outer sulcus cells play a role in inner ear fluid homeostasis. However, their anatomy and distribution in the human are not well described.Methods:Temporal bone specimens with normal hearing (n=10), Meniere's disease (n=10), presbycusis with flat audiograms (n=4), and presbycusis with sloping audiograms (n=5) were examined by light microscopy. Outer sulcus cells were assessed quantitatively and qualitatively in each cochlear turn. One specimen was stained for tubulin immunofluorescence and imaged using confocal microscopy.Results:Outer sulcus cells interface with endolymph throughout the cochlea, with greatest contact in the apical turn. Mean outer sulcus cell counts in the upper apical turn (8.82) were generally smaller (all p
