Role of MBD3-SOX2 axis in residual myeloma following pomalidomide.
Role of MBD3-SOX2 axis in residual myeloma following pomalidomide.
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MBD3-SOX2轴在pomalidomide后残留骨髓瘤中的作用。
DOI：
10.1038/s41375-021-01145-0
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发表时间：
2021-11
期刊：
影响因子：
11.4
通讯作者：
Dhodapkar MV
中科院分区：
文献类型：
--
作者：
Verma R;Branagan AR;Xu ML;Flavell RA;Dhodapkar KM;Dhodapkar MV
MethodsStudy designIn order to study the biology of residual MM following Pom, MM cells were exposed to the drug (100–300 ng/mL) or DMSO control in vitro and then utilized for subsequent experiments with indicated doses equivalent to the therapeutic concentrations achieved in vivo [6]. INA-6 cells xenografted into RGS6 mice [7] were utilized to study growth of MM cells in vivo using the intra-femoral delivery of MM cells as described earlier (Supplementary Fig. S1)[8]. Biospecimens obtained under the auspices of a clinical trial of pomalidomide (NCT01319422) in relapsed MM [9] were utilized to evaluate the effects of Pom on primary MM cells in vivo. All biospecimens were obtained following informed consent approved by Yale IRB and all animal studies were performed in accordance with protocols approved by Yale IACUC. Details of methods are noted under supplementary methods.
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影响因子：
11.4
作者：
Lopez-Girona, A.;Mendy, D.;Ito, T.;Miller, K.;Gandhi, A. K.;Kang, J.;Karasawa, S.;Carmel, G.;Jackson, P.;Abbasian, M.;Mahmoudi, A.;Cathers, B.;Rychak, E.;Gaidarova, S.;Chen, R.;Schafer, P. H.;Handa, H.;Daniel, T. O.;Evans, J. F.;Chopra, R.
通讯作者：
Chopra, R.
影响因子：
11.2
作者：
Matsui, William;Wang, Qiuju;Jones, Richard J.
通讯作者：
Jones, Richard J.
影响因子：
6.5
作者：
Gandhi AK;Kang J;Havens CG;Conklin T;Ning Y;Wu L;Ito T;Ando H;Waldman MF;Thakurta A;Klippel A;Handa H;Daniel TO;Schafer PH;Chopra R
通讯作者：
Chopra R
影响因子：
64.8
作者：
Rais, Yoach;Zviran, Asaf;Hanna, Jacob H.
通讯作者：
Hanna, Jacob H.
影响因子：
20.3
作者：
Zhu, Yuan Xiao;Braggio, Esteban;Stewart, A. Keith
通讯作者：
Stewart, A. Keith