Cortistatin A is a High-Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11
Cortistatin A is a High-Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11
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DOI：
10.1002/anie.200904778
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Nicolaou, K. C.
中科院分区：
文献类型：
--
作者：
Cee, Victor J.;Chen, David Y. -K.;Nicolaou, K. C.
抗增殖生物碱：皮质激素A是一小部分蛋白激酶的高亲和力配体，包括Rho相关的、含卷曲螺旋的蛋白激酶（ROCK）、细胞周期蛋白依赖性激酶8（CDK 8）和细胞周期蛋白依赖性激酶11（CDK 11）。皮质抑素A与ROCK晶体结构结合的模型（见图）和CDK8的同源模型
Antiproliferative alkaloid: Cortistatin A is a high-affinity ligand for a small set of protein kinases including Rho-associated, coiled-coil-containing protein kinase (ROCK), cyclin-dependent kinase 8 (CDK8), and cyclin-dependent kinase 11 (CDK11). Models of cortistatin A bound to a crystallographic structure of ROCK (see picture) and a homology model of CDK8 are presented