DISSEMINATED PENICILLIUM-MARNEFFEI INFECTION IN HIV-INFECTED SUBJECT
DISSEMINATED PENICILLIUM-MARNEFFEI INFECTION IN HIV-INFECTED SUBJECT
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DOI：
10.1111/j.1365-2559.1992.tb00985.x
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发表时间：
1992-04-01
期刊：
影响因子：
6.4
通讯作者：
TSANG, DNC
中科院分区：
文献类型：
--
作者：
TSUI, WMS;MA, KF;TSANG, DNC
马尔尼菲青霉菌是一种罕见的人类病原体，主要影响东南亚居民。 我们报告了香港发生的四例人类免疫缺陷病毒感染患者死亡病例。 通过组织学检查确定诊断，并通过真菌分离证实。 感染呈播散性，累及淋巴结、肝、脾、肺、肠和骨髓。 所涉及的器官表现出完全无反应的组织反应，其特征是充满真菌的巨噬细胞的弥漫性浸润、多种共存的机会性感染和淋巴细胞耗竭。 该生物体必须与荚膜组织胞浆菌和卡氏肺孢子虫区分开来。 诊断的确定很重要，不仅因为这种感染有可能治愈，而且它可能是东南亚艾滋病的指示性疾病。 对于来自或去过东南亚流行地区的任何有症状的艾滋病毒阳性患者，都应怀疑马尔尼菲青霉病。
Penicillium marneffei is a rare human pathogen predominantly affecting residents of South-east Asia. We report four fatal cases from Hong Kong in human immunodeficiency virus-infected patients. The diagnosis was established by histological examination and confirmed by isolation of the fungus. The infection was disseminated with involvement of lymph nodes, liver, spleen, lung, intestine and bone marrow. The involved organs showed an exclusively anergic tissue reaction characterized by a diffuse infiltrate of fungi-laden macrophages, multiple co-existing opportunistic infections and lymphoid cell depletion. This organism has to be distinguished from Histoplasma capsulatum and Pneumocystis carinii. Establishment of the diagnosis is important not only because this infection is potentially curable, but also it is a likely indicator disease of AIDS in South-east Asia. Penicilliosis marneffei should be suspected in any symptomatic HIV-positive patient who comes from or has visited endemic areas of South-east Asia.