Effects of risedronate on cortical and trabecular bone of the mandible in glucocorticoid-treated growing rats
Effects of risedronate on cortical and trabecular bone of the mandible in glucocorticoid-treated growing rats
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DOI：
10.1016/j.ajodo.2009.05.028
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发表时间：
2011-03-01
影响因子：
3
通讯作者：
Maki, Kenshi
中科院分区：
文献类型：
--
作者：
Fujita, Yuko;Watanabe, Koji;Maki, Kenshi
简介：本研究旨在评估利塞膦酸钠对生长期大鼠糖皮质激素诱导的骨质疏松症的下颌骨骨密度、骨结构和骨代谢的影响。研究方法：大鼠口服泼尼松龙30 mg/kg/2 d，连续6周后，分别口服利塞膦酸钠0、0.5、1.0 mg/kg/d，连续4周。通过外周定量计算机断层扫描分析小梁和皮质骨质量，并通过静态和动态组织形态计量学测量骨结构和骨形成。结果：在松质骨中，利塞膦酸钠改善了泼尼松龙引起的骨横截面积和骨矿含量的减少。利塞膦酸钠增加骨密度，并通过降低骨转换率形成致密的骨微结构。在皮质骨中，利塞膦酸钠通过增加矿化表面改善了泼尼松龙诱导的骨横截面积和骨矿物质含量的减少，而不影响骨密度。结论：利塞膦酸钠改善泼尼松龙诱导的骨小梁和皮质骨生长迟缓，但这两个部位的骨转换在生长的大鼠下颌骨中受到不同的调节。(Am J Orthod Dentofacial Orthop 2011;139：e267-e277）
Introduction: This study was performed to estimate the effects of risedronate on mandibular bone density, bone structure, and bone metabolism in established glucocorticoid-induced osteoporosis in growing rats. Methods: The rats were given oral risedronate at 0, 0.5, or 1.0 mg per kilogram per day for 4 weeks after the administration of oral prednisolone at 30 mg per kilogram per 2 days for 6 weeks. Trabecular and cortical bone masses were analyzed by using peripheral quantitative computed tomography, and bone structure and bone formation were measured by using static and dynamic histomorphometry. Results: In trabecular bone, risedronate improved the prednisolone-induced decreases in bone cross-sectional area and bone mineral content. Risedronate increased bone density and also formed dense bone microarchitecture by reducing the bone turnover rate. In cortical bone, risedronate improved the prednisolone-induced decreases in bone cross-sectional area and bone mineral content without affecting bone density by increasing the mineralizing surface. Conclusions: Risedronate improved prednisolone-induced retardation of trabecular and cortical bone growth, but the bone turnover in these 2 sites was regulated differently in the growing rat mandibles. (Am J Orthod Dentofacial Orthop 2011;139:e267-e277)