Synovial Sarcoma in Childhood and Adolescence: A Retrospective Series of 77 Patients Registered by the Children's Cancer and Leukaemia Group Between 1991 and 2006
Synovial Sarcoma in Childhood and Adolescence: A Retrospective Series of 77 Patients Registered by the Children's Cancer and Leukaemia Group Between 1991 and 2006
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DOI：
10.1002/pbc.22453
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发表时间：
2010-07-15
影响因子：
3.2
通讯作者：
Stiller, Charles A.
中科院分区：
文献类型：
--
作者：
Brennan, Bernadette;Stevens, Michael;Stiller, Charles A.
Background. The analysis of a contemporary multi-centre series of synovial sarcoma in children and young people describes the clinical characteristics, examines the effect of known prognostic factors and looks at outcome with particular emphasis on a conservative approach to treatment of localised disease. Procedure. Data from 77 young patients with synovial sarcoma registered or treated by the Children's Cancer and Leukaemia Group (CCLG) between 1991 and 2006 were reviewed. The outcome of 21 patients with localised favourable disease who were treated with surgery only is described. Results. Five-year event-free survival (EFS) and overall survival (OS) for all 77 patients were 72% and 76%, respectively. In multivariate analysis survival was influenced by tumour invasiveness and size (T stage) and IRS group (T1b, P=0.002; T2a, P=0.041; T2b, P
