SPONTANEOUS ASYMMETRIC CIRCLING BEHAVIOR IN HEMI-PARKINSONISM - A HUMAN EQUIVALENT OF THE LESIONED-CIRCLING RODENT BEHAVIOR
SPONTANEOUS ASYMMETRIC CIRCLING BEHAVIOR IN HEMI-PARKINSONISM - A HUMAN EQUIVALENT OF THE LESIONED-CIRCLING RODENT BEHAVIOR
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DOI：
10.1016/0024-3205(87)90576-5
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发表时间：
1987-03-16
期刊：
影响因子：
6.1
通讯作者：
KLEINMAN, JE
中科院分区：
文献类型：
--
作者：
BRACHA, HS;SHULTS, C;KLEINMAN, JE
在啮齿类动物实验中，基底神经节多巴胺的半球不对称导致自发的向多巴胺水平较低的半球不对称旋转。长期以来，人们一直认为半帕金森患者的大脑中也存在类似的不对称。使用电子旋转计数器，我们证明了像单侧受损的大鼠一样，在没有意识到的情况下，5名半帕金森病门诊患者向纹状体多巴胺能活性较低的半球自发旋转。
When induced experimentally in rodents, hemispheric assymetry in basal ganglia dopamine results in spontaneous asymmetric circling toward the hemisphere with the lower level of dopamine. A similar asymmetry has long been thought to exist in the brains of hemi-Parkinsonian patients. Using an electronic turn counter, we demonstrated that like unilaterally lesioned rats, and without being aware of it, five ambulating outpatients with hemi-Parkinson''s disease exhibit spontaneous rotation toward the hemisphere containing less striatal dopaminergic activity.