Immunoglobulin A antibodies directed against Campylobacter jejuni flagellin present in breast-milk.
Immunoglobulin A antibodies directed against Campylobacter jejuni flagellin present in breast-milk.
复制标题
针对母乳中存在的空肠弯曲杆菌鞭毛蛋白的免疫球蛋白 A 抗体。
DOI：
10.1017/s0950268800057769
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发表时间：
1994
影响因子：
4.2
通讯作者：
Cravioto,A
中科院分区：
文献类型：
--
作者：
Nachamkin,I;Fischer,SH;Yang,XH;Benitez,O;Cravioto,A
我们研究了母乳样本中伊加抗弯曲杆菌鞭毛蛋白抗体与保护生活在墨西哥乡村的母乳喂养婴儿免受弯曲杆菌感染之间的关系。与非母乳喂养的儿童（3.3/儿童/年，95%CI 1.8-4.8; P < 0.01）相比，母乳喂养的婴儿中含有特异性抗鞭毛蛋白抗体的弯曲杆菌感染（症状性和无症状性合并）发生率更低（1.2/儿童/年，95%CI 0.6-1.8）。与非母乳喂养的儿童相比，母乳喂养的婴儿抗鞭毛蛋白抗体ELISA检测阴性，感染次数也较少，但差异未达到统计学显著性（1.8/儿童/年，95%CI 0.7-3.0 vs 3.3/儿童/年，95%CI 1.8-4.8，P > 0.05）。母乳喂养对弯曲杆菌感染具有保护作用，并且与针对弯曲杆菌鞭毛蛋白的特异性抗体的存在有关。
We studied the relationship between IgA anti–campylobacter flagellin antibodies in breast milk samples and protection of breastfed infants living in a rural Mexican village from campylobacter infection. There were fewer episodes of campylobacter infection (symptomatic and asymptomatic combined) in infants breastfed with milk containing specific anti-flagellin antibodies (1.2/child/year, 95% CI 0.6–1.8) versus non–breastfed children (3.3/child/year, 95% CI 1.8–4.8; P < 0.01). Infants breastfed with milk that was antiflagellin antibody negative by ELISA also had fewer episodes of infection compared with non-breastfed children, but the difference did not reach statistical significance (1.8/child/year, 95% CI 0.7–3.0 versus 3.3/child/year, 95% CI 1.8–4.8, P > 0.05). Breastfeeding has a protective effect against campylobacter infection and is associated with the presence of specific antibodies directed against campylobacter flagellin.