The Side Effects of Silver Sulfadiazine
The Side Effects of Silver Sulfadiazine
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DOI：
10.1097/bcr.0b013e3181a28c9b
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发表时间：
2009-05-01
影响因子：
1.4
通讯作者：
Fuller, Frederick W.
中科院分区：
文献类型：
--
作者：
Fuller, Frederick W.
磺胺嘧啶银霜在烧伤治疗中具有令人羡慕的安全记录。然而，其副作用，例如对磺胺嘧啶部分的过敏反应、治疗的烧伤伤口的银染色、高渗透压、高铁血红蛋白血症和由于先天性缺乏葡萄糖-6-磷酸脱氢酶引起的溶血，可能被遗漏或误解。烧伤后早期白细胞减少症曾被认为是在烧伤伤口治疗中使用磺胺嘧啶银的副作用，但现在不再被认为是副作用，因为已经发现使用其他烧伤局部药物也会发生这种情况。它的存在不再是停止磺胺嘧啶银烧伤创面治疗的指征。由于这些副作用是罕见的，任何一个医生或烧伤设施通常在诊断和治疗他们的经验有限。（J Burn Care Res 2009;30：464-470）
Silver sulfadiazine cream has an enviable safety record in burn treatment. However, it side effects, exemplified by allergic reactions to its sulfadiazine moiety, silver staining of the treated burn wound, hyperosmolality, methemoglobinemia, and hemolysis due to a congential lack of glucose-6-phospate dehydrogenase, may be missed or misinterpreted. Early post burn leukopenia, once thought to be a side effect of the use of silver sulfadiazine in burn wound therapy, is no longer regarded as such since it has been found to occur with the use of other burn topical agents. Its presence is no longer an indication to discontinue silver sulfadiazine burn wound therapy. Because these side effects are uncommon, any one physician or burn facility usually has limited experience in diagnosing and treating them. (J Burn Care Res 2009;30:464-470)